Mapping quantitative trait loci for open-field behavior in mice

Howard K. Gershenfeld, Paul E. Neumann, Chantal Mathis, Jacqueline Crawley, Xiaohua Li, Steven M. Paul

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

By performing a whole genome screen in an F2 intercross of two strains of mice (A/J and C57BL/6J), which differ markedly in their behavioral response to a brightly lit open field (O-F) we have mapped several quantitative trait loci (QTL) for this complex behavioral phenotype. QTL on chromosomes 1 and 10 were identified that affect both initial ambulation in the O-F (initial 'response to novelty' ambulation) (lod of 7.1 and 8.8, respectively) and vertical rearings (lod of 4.5 and 8.5, respectively). For habituated O-F behavior, QTL were identified on chromosomes 3 and 10 for ambulation (lod of 4.1 and 14.7, respectively) and on chromosomes 1, 10, and 19 for vertical rearings (lod of 5.8, 6.0, and 4.7, respectively). The QTL on chromosome 1 (near D1Mit116; 101 cM) was specific for initial O-F ambulation behavior, whereas the QTL on chromosome 10 (near D10Mit237; 74 cM) affected both initial and habituated rearing behavior. Additional suggestive QTL (lod, >2.8) were mapped to chromosomes 1, 8, 11, 15, and 19. The QTL on chromosomes 1, 10, and 19 individually explain from 3.2 to 12.7%. Collectively, the multiple independent QTL explain from 16.3 to 24.1% of the F2 population's phenotypic variance, depending on the trait. These identified QTL should prove useful for dissecting the genetic and behavioral dimensions of O-F behavior, fostering an understanding of individual differences.

Original languageEnglish (US)
Pages (from-to)201-210
Number of pages10
JournalBehavior Genetics
Volume27
Issue number3
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Quantitative Trait Loci
chromosome
quantitative trait loci
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 1
mice
chromosomes
Walking
rearing
Chromosomes, Human, Pair 19
Behavioral Genetics
behavioral response
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 3
Foster Home Care
phenotype
genome
phenotypic variation
Individuality
Genome

Keywords

  • Chromosomal mapping
  • Exploratory behavior
  • Habituation
  • Novelty
  • Quantitative trait loci (QTL)

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Behavioral Neuroscience
  • Psychology(all)

Cite this

Gershenfeld, H. K., Neumann, P. E., Mathis, C., Crawley, J., Li, X., & Paul, S. M. (1997). Mapping quantitative trait loci for open-field behavior in mice. Behavior Genetics, 27(3), 201-210. https://doi.org/10.1023/A:1025653812535

Mapping quantitative trait loci for open-field behavior in mice. / Gershenfeld, Howard K.; Neumann, Paul E.; Mathis, Chantal; Crawley, Jacqueline; Li, Xiaohua; Paul, Steven M.

In: Behavior Genetics, Vol. 27, No. 3, 1997, p. 201-210.

Research output: Contribution to journalArticle

Gershenfeld, HK, Neumann, PE, Mathis, C, Crawley, J, Li, X & Paul, SM 1997, 'Mapping quantitative trait loci for open-field behavior in mice', Behavior Genetics, vol. 27, no. 3, pp. 201-210. https://doi.org/10.1023/A:1025653812535
Gershenfeld, Howard K. ; Neumann, Paul E. ; Mathis, Chantal ; Crawley, Jacqueline ; Li, Xiaohua ; Paul, Steven M. / Mapping quantitative trait loci for open-field behavior in mice. In: Behavior Genetics. 1997 ; Vol. 27, No. 3. pp. 201-210.
@article{5505a8ed93884224a37b5da443cb173f,
title = "Mapping quantitative trait loci for open-field behavior in mice",
abstract = "By performing a whole genome screen in an F2 intercross of two strains of mice (A/J and C57BL/6J), which differ markedly in their behavioral response to a brightly lit open field (O-F) we have mapped several quantitative trait loci (QTL) for this complex behavioral phenotype. QTL on chromosomes 1 and 10 were identified that affect both initial ambulation in the O-F (initial 'response to novelty' ambulation) (lod of 7.1 and 8.8, respectively) and vertical rearings (lod of 4.5 and 8.5, respectively). For habituated O-F behavior, QTL were identified on chromosomes 3 and 10 for ambulation (lod of 4.1 and 14.7, respectively) and on chromosomes 1, 10, and 19 for vertical rearings (lod of 5.8, 6.0, and 4.7, respectively). The QTL on chromosome 1 (near D1Mit116; 101 cM) was specific for initial O-F ambulation behavior, whereas the QTL on chromosome 10 (near D10Mit237; 74 cM) affected both initial and habituated rearing behavior. Additional suggestive QTL (lod, >2.8) were mapped to chromosomes 1, 8, 11, 15, and 19. The QTL on chromosomes 1, 10, and 19 individually explain from 3.2 to 12.7{\%}. Collectively, the multiple independent QTL explain from 16.3 to 24.1{\%} of the F2 population's phenotypic variance, depending on the trait. These identified QTL should prove useful for dissecting the genetic and behavioral dimensions of O-F behavior, fostering an understanding of individual differences.",
keywords = "Chromosomal mapping, Exploratory behavior, Habituation, Novelty, Quantitative trait loci (QTL)",
author = "Gershenfeld, {Howard K.} and Neumann, {Paul E.} and Chantal Mathis and Jacqueline Crawley and Xiaohua Li and Paul, {Steven M.}",
year = "1997",
doi = "10.1023/A:1025653812535",
language = "English (US)",
volume = "27",
pages = "201--210",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Mapping quantitative trait loci for open-field behavior in mice

AU - Gershenfeld, Howard K.

AU - Neumann, Paul E.

AU - Mathis, Chantal

AU - Crawley, Jacqueline

AU - Li, Xiaohua

AU - Paul, Steven M.

PY - 1997

Y1 - 1997

N2 - By performing a whole genome screen in an F2 intercross of two strains of mice (A/J and C57BL/6J), which differ markedly in their behavioral response to a brightly lit open field (O-F) we have mapped several quantitative trait loci (QTL) for this complex behavioral phenotype. QTL on chromosomes 1 and 10 were identified that affect both initial ambulation in the O-F (initial 'response to novelty' ambulation) (lod of 7.1 and 8.8, respectively) and vertical rearings (lod of 4.5 and 8.5, respectively). For habituated O-F behavior, QTL were identified on chromosomes 3 and 10 for ambulation (lod of 4.1 and 14.7, respectively) and on chromosomes 1, 10, and 19 for vertical rearings (lod of 5.8, 6.0, and 4.7, respectively). The QTL on chromosome 1 (near D1Mit116; 101 cM) was specific for initial O-F ambulation behavior, whereas the QTL on chromosome 10 (near D10Mit237; 74 cM) affected both initial and habituated rearing behavior. Additional suggestive QTL (lod, >2.8) were mapped to chromosomes 1, 8, 11, 15, and 19. The QTL on chromosomes 1, 10, and 19 individually explain from 3.2 to 12.7%. Collectively, the multiple independent QTL explain from 16.3 to 24.1% of the F2 population's phenotypic variance, depending on the trait. These identified QTL should prove useful for dissecting the genetic and behavioral dimensions of O-F behavior, fostering an understanding of individual differences.

AB - By performing a whole genome screen in an F2 intercross of two strains of mice (A/J and C57BL/6J), which differ markedly in their behavioral response to a brightly lit open field (O-F) we have mapped several quantitative trait loci (QTL) for this complex behavioral phenotype. QTL on chromosomes 1 and 10 were identified that affect both initial ambulation in the O-F (initial 'response to novelty' ambulation) (lod of 7.1 and 8.8, respectively) and vertical rearings (lod of 4.5 and 8.5, respectively). For habituated O-F behavior, QTL were identified on chromosomes 3 and 10 for ambulation (lod of 4.1 and 14.7, respectively) and on chromosomes 1, 10, and 19 for vertical rearings (lod of 5.8, 6.0, and 4.7, respectively). The QTL on chromosome 1 (near D1Mit116; 101 cM) was specific for initial O-F ambulation behavior, whereas the QTL on chromosome 10 (near D10Mit237; 74 cM) affected both initial and habituated rearing behavior. Additional suggestive QTL (lod, >2.8) were mapped to chromosomes 1, 8, 11, 15, and 19. The QTL on chromosomes 1, 10, and 19 individually explain from 3.2 to 12.7%. Collectively, the multiple independent QTL explain from 16.3 to 24.1% of the F2 population's phenotypic variance, depending on the trait. These identified QTL should prove useful for dissecting the genetic and behavioral dimensions of O-F behavior, fostering an understanding of individual differences.

KW - Chromosomal mapping

KW - Exploratory behavior

KW - Habituation

KW - Novelty

KW - Quantitative trait loci (QTL)

UR - http://www.scopus.com/inward/record.url?scp=0030999378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030999378&partnerID=8YFLogxK

U2 - 10.1023/A:1025653812535

DO - 10.1023/A:1025653812535

M3 - Article

C2 - 9210791

AN - SCOPUS:0030999378

VL - 27

SP - 201

EP - 210

JO - Behavior Genetics

JF - Behavior Genetics

SN - 0001-8244

IS - 3

ER -