Mapping Panel

C. Wu, N. E. Cockett, Michael F Seldin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A mapping panel is a collection of DNA samples that are typed with genetic markers. The resulting data are analyzed in order to define the relative order and the distance between genes on a single chromosome or across all chromosomes in the genome. DNA mapping panels have been extensively used for developing genetic linkage maps in mice. This type of panel is generally developed from backcrosses of subspecies or species of mice that are genetically different. Segregation of genetic markers is analyzed within the mapping panels to determine which markers are inherited together and therefore found in close proximity on the chromosome. Within the last decade, chromosomal maps have been generated for non-mouse mammalian species using radiation hybrid (RH) panels. In this approach, the presence of genetic markers within the same sample in the RH panel indicates that the markers are located in close proximity on the chromosome. The RH panels provide information regarding the distance between almost any genetic marker, including nonpolymorphic genetic markers and anonymous sequence fragments. RD panels with varying dosages of radiation are now available for many mammalian species. However, in both mouse and human, complete genome sequence data have replaced mapping panels as the framework for relative position of DNA markers.

Original languageEnglish (US)
Title of host publicationBrenner's Encyclopedia of Genetics
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages308-309
Number of pages2
ISBN (Electronic)9780080961569
ISBN (Print)9780123749840
DOIs
StatePublished - Feb 27 2013

Keywords

  • Chromosome
  • DNA mapping panel
  • Gene
  • Genetic linkage map
  • Genetic marker
  • Radiation hybrid map
  • Radiation hybrid panel

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Wu, C., Cockett, N. E., & Seldin, M. F. (2013). Mapping Panel. In Brenner's Encyclopedia of Genetics: Second Edition (pp. 308-309). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374984-0.00902-5