Purpose. In order to monitor blood flow during the treatment of glaucoma and to detect abnomalities in the vascular achitecture which may correspond to malignancy, a strategy for mapping the vascular tree has been developed. Initially, this strategy has been used to study flow through the ciliary body and flow phantoms. Methods. Using high-frequency (50 MHz) ultrasound, high resolution M-mode images of the ciliary body of rabbits and human subjects have been obtained. An in-vitro three dimensional (3-D) color flow map of a phantom composed of 200 um vessels was then developed. Using a new recursive algorithm, vessels in adjacent 2-D slices are connected and the vascular tree can be manipulated. Results. High resolution M-mode images allow for the visualization of wall pulsatility, and changes in velocity with the cardiac cycle. Velocities as low as 0.4 mm/s can be distinguished from surrounding tissue. Reconstruction of the vascular tree provides the opportunity to study the density of vessels in individual regions, and the architectural structure of the vasculature. Conclusions. The volume and velocity of blood flow can be used to develop spatial maps of the vascular architecture, with the goal of detecting changes in flow during drug therapy and changes produced by a malignancy.
|Original language||English (US)|
|Journal||Investigative Ophthalmology and Visual Science|
|State||Published - Feb 15 1996|
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