Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXRα, RXRβ, and RXRγ

Charles W. Hoopes, Makoto Taketo, Kieko Ozato, Qiang Liu, Thad A. Howard, Elwood Linney, Michael F Seldin

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Recently, a novel subgroup of nuclear hormone receptors called RXRs implicated for retinoid-mediated gene regulation have been identified. RXRs appear to interact with many other nuclear hormone receptors and modulate their functions. We have mapped genetic loci Rxra, Rxrb, and Rxrg encoding three RXR subtypes, RXRα, RXRβ, and RXRγ, respectively, using interspecific backcross mice. None of the Rxr loci cosegregated with each other or with the retinoic acid receptor loci (Rar) mapped previously. Rxra mapped to Chr 2 near the centromere, Rxrb mapped to the H-2 region of Chr 17, and Rxrg was tightly linked to the Pbx gene on distal Chr 1. These results underscore that RXR genes are dispersed in the genome.

Original languageEnglish (US)
Pages (from-to)611-617
Number of pages7
JournalGenomics
Volume14
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Genetics

Cite this