Abstract
Recently, a novel subgroup of nuclear hormone receptors called RXRs implicated for retinoid-mediated gene regulation have been identified. RXRs appear to interact with many other nuclear hormone receptors and modulate their functions. We have mapped genetic loci Rxra, Rxrb, and Rxrg encoding three RXR subtypes, RXRα, RXRβ, and RXRγ, respectively, using interspecific backcross mice. None of the Rxr loci cosegregated with each other or with the retinoic acid receptor loci (Rar) mapped previously. Rxra mapped to Chr 2 near the centromere, Rxrb mapped to the H-2 region of Chr 17, and Rxrg was tightly linked to the Pbx gene on distal Chr 1. These results underscore that RXR genes are dispersed in the genome.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 611-617 |
| Number of pages | 7 |
| Journal | Genomics |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Genetics
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Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXRα, RXRβ, and RXRγ. / Hoopes, Charles W.; Taketo, Makoto; Ozato, Kieko; Liu, Qiang; Howard, Thad A.; Linney, Elwood; Seldin, Michael F.
In: Genomics, Vol. 14, No. 3, 1992, p. 611-617.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mapping of the mouse Rxr loci encoding nuclear retinoid X receptors RXRα, RXRβ, and RXRγ
AU - Hoopes, Charles W.
AU - Taketo, Makoto
AU - Ozato, Kieko
AU - Liu, Qiang
AU - Howard, Thad A.
AU - Linney, Elwood
AU - Seldin, Michael F
PY - 1992
Y1 - 1992
N2 - Recently, a novel subgroup of nuclear hormone receptors called RXRs implicated for retinoid-mediated gene regulation have been identified. RXRs appear to interact with many other nuclear hormone receptors and modulate their functions. We have mapped genetic loci Rxra, Rxrb, and Rxrg encoding three RXR subtypes, RXRα, RXRβ, and RXRγ, respectively, using interspecific backcross mice. None of the Rxr loci cosegregated with each other or with the retinoic acid receptor loci (Rar) mapped previously. Rxra mapped to Chr 2 near the centromere, Rxrb mapped to the H-2 region of Chr 17, and Rxrg was tightly linked to the Pbx gene on distal Chr 1. These results underscore that RXR genes are dispersed in the genome.
AB - Recently, a novel subgroup of nuclear hormone receptors called RXRs implicated for retinoid-mediated gene regulation have been identified. RXRs appear to interact with many other nuclear hormone receptors and modulate their functions. We have mapped genetic loci Rxra, Rxrb, and Rxrg encoding three RXR subtypes, RXRα, RXRβ, and RXRγ, respectively, using interspecific backcross mice. None of the Rxr loci cosegregated with each other or with the retinoic acid receptor loci (Rar) mapped previously. Rxra mapped to Chr 2 near the centromere, Rxrb mapped to the H-2 region of Chr 17, and Rxrg was tightly linked to the Pbx gene on distal Chr 1. These results underscore that RXR genes are dispersed in the genome.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026595295&partnerID=8YFLogxK
U2 - 10.1016/S0888-7543(05)80159-4
DO - 10.1016/S0888-7543(05)80159-4
M3 - Article
C2 - 1358808
AN - SCOPUS:0026595295
VL - 14
SP - 611
EP - 617
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 3
ER -