Mapping of the mouse Rar loci encoding retinoic acid receptors RARα, RARβ and RARγ

M. Taketo, C. Hoopes, T. A. Howard, E. Linney, Michael F Seldin

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Nuclear retinoic acid receptors RARα, RARβ and RARγ are transcription factors that bind all-trans retinoic acid as their ligand and mediate its action by activating particular sets of genes that contain retinoic acid responsive elements in their promoter-enhancers. We have mapped genetic loci for these genes using restriction fragment length variants (RFLVs) in interspecific backcross mice. None of the Rar loci cosegregated with each other or with the new subclass of retinoid receptors, Rxr loci. Rara mapped to mChr 11, Rarb mapped to mChr 14, and Rarg mapped to mChr 15. The results are consistent with the previous reports and the human data in terms of syntenic homology between mouse and human chromosomes.

Original languageEnglish (US)
Pages (from-to)175-184
Number of pages10
JournalJapanese Journal of Genetics
Volume68
Issue number3
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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