Mapping of the Genes Encoding Mouse Thromboxane A2 Receptor and Prostaglandin E Receptor Subtypes EP2 and EP3

Makoto Taketo, Julie M. Rochelle, Yukihiko Sugimoto, Tsunehisa Namba, Akiko Honda, Manabu Negishi, Atsushi Ichikawa, Shu Narumiya, Michael F Seldin

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Thromboxane A2 (TXA2) and prostaglandin E2 (PGE2) are two of the most representative eicosanoids that are formed from arachidonic acid. They produce a broad spectrum of biological effects mediated through specific cell surface receptors. We have mapped genetic loci for TXA2 receptor, Tbxa2r, and for PGE2 receptor subtypes EP2 and EP3, Ptgerep2 and Ptgerep3, respectively, using restriction fragment length variants in interspecific backcross mice. None of the three loci cosegregated with each other. Tbxa2r mapped to Chr 10, Ptgerep2 mapped to the centromeric region of Chr 15, and Ptgerep3 mapped to the distal end of Chr 3. Possible human loci for these receptors are predicted based on the homology between mouse and human chromosomes.

Original languageEnglish (US)
Pages (from-to)585-588
Number of pages4
JournalGenomics
Volume19
Issue number3
DOIs
StatePublished - Feb 1994
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Mapping of the Genes Encoding Mouse Thromboxane A<sub>2</sub> Receptor and Prostaglandin E Receptor Subtypes EP<sub>2</sub> and EP<sub>3</sub>'. Together they form a unique fingerprint.

  • Cite this

    Taketo, M., Rochelle, J. M., Sugimoto, Y., Namba, T., Honda, A., Negishi, M., Ichikawa, A., Narumiya, S., & Seldin, M. F. (1994). Mapping of the Genes Encoding Mouse Thromboxane A2 Receptor and Prostaglandin E Receptor Subtypes EP2 and EP3. Genomics, 19(3), 585-588. https://doi.org/10.1006/geno.1994.1113