Mapping of the calcium-sensing receptor gene (CASR) to human Chromosome 3q13.3-21 by fluorescence in situ hybridization, and localization to rat Chromosome 11 and mouse Chromosome 16

N. Janicic, E. Soliman, Z. Pausova, Michael F Seldin, M. Rivière, J. Szpirer, C. Szpirer, G. N. Hendy

Research output: Contribution to journalArticle

96 Scopus citations

Abstract

The calcium-sensing receptor (CASR), a member of the G-protein coupled receptor family, is expressed in both parathyroid and kidney, and aids these organs in sensing extracellular calcium levels. Inactivating mutations in the CASR gene have been described in familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Activating mutations in the CASR gene have been described in autosomal dominant hypoparathyroidism and familial hypocalcemia. The human CASR gene was mapped to Chromosome (Chr) 3q13.3-21 by fluorescence in situ hybridization (FISH). By somatic cell hybrid analysis, the gene was localized to human Chr 3 (hybridization to other chromosomes was not observed) and rat Chr 11. By interspecific backcross analysis, the Casr gene segregated with D16Mit4 on mouse Chr 16. These findings extend our knowledge of the synteny conservation of human Chr 3, rat Chr 11, and mouse Chr 16.

Original languageEnglish (US)
Pages (from-to)798-801
Number of pages4
JournalMammalian Genome
Volume6
Issue number11
DOIs
StatePublished - Nov 1995
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Genetics

Cite this