Mapping of the bcl-2 oncogene on mouse chromosome 1.

B. A. Mock, D. Givol, L. A. D'Hoostelaere, K. Huppi, Michael F Seldin, N. Gurfinkel, T. Unger, M. Potter, J. F. Mushinski

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Two bcl-2 alleles have been identified in inbred strains of mice by restriction fragment length polymorphism (RFLP). Analysis of a bcl-2 RFLP in a series of bilineal congenic strains (C.D2), developed as a tool for chromosomal mapping studies, revealed linkage of bcl-2 to the Idh-1/Pep-3 region of murine chromosome 1. The co-segregation of bcl-2 alleles with allelic forms of two other chromosome 1 loci, Ren-1,2 and Spna-1, in a set of back-cross progeny, positions bcl-2 7.8 cM centromeric from Ren-1,2.

Original languageEnglish (US)
Pages (from-to)11-15
Number of pages5
JournalCytogenetics and Cell Genetics
Volume47
Issue number1-2
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology
  • Genetics

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    Mock, B. A., Givol, D., D'Hoostelaere, L. A., Huppi, K., Seldin, M. F., Gurfinkel, N., Unger, T., Potter, M., & Mushinski, J. F. (1988). Mapping of the bcl-2 oncogene on mouse chromosome 1. Cytogenetics and Cell Genetics, 47(1-2), 11-15.