Mapping of the 75-kDa Inositol Polyphosphate-5-Phosphatase (Inpp5b) to Distal Mouse Chromosome 4 and Its Exclusion as a Candidate Gene for dysgenetic lens

Pasi A. Jänne, Julie M. Rochelle, Patricia A. Martin-DeLeon, Dwight Stambolian, Michael F Seldin, Robert L. Nussbaum

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We have determined the chromosomal localization of the murine gene encoding a 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b). Using two independent approaches, fluorescence in situ hybridization and interspecific backcross analysis, we show that Inpp5b maps to distal mouse Chromosome 4. This map position is within the conserved linkage group corresponding to the short arm of human Chromosome 1, where the human homologue, INPP5B, has been shown to map previously. The position of Inpp5b on amuse Chromosome 4 is in the vicinity of the mouse developmental mutation dysgenetic lens (dyl). However, using a genetic approach, we show that Inpp5b maps distal to dyl on mouse Chromosome 4.

Original languageEnglish (US)
Pages (from-to)280-285
Number of pages6
JournalGenomics
Volume28
Issue number2
DOIs
StatePublished - Jul 20 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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