Abstract
We have determined the chromosomal localization of the murine gene encoding a 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b). Using two independent approaches, fluorescence in situ hybridization and interspecific backcross analysis, we show that Inpp5b maps to distal mouse Chromosome 4. This map position is within the conserved linkage group corresponding to the short arm of human Chromosome 1, where the human homologue, INPP5B, has been shown to map previously. The position of Inpp5b on amuse Chromosome 4 is in the vicinity of the mouse developmental mutation dysgenetic lens (dyl). However, using a genetic approach, we show that Inpp5b maps distal to dyl on mouse Chromosome 4.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 280-285 |
| Number of pages | 6 |
| Journal | Genomics |
| Volume | 28 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 20 1995 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Genetics
Cite this
Mapping of the 75-kDa Inositol Polyphosphate-5-Phosphatase (Inpp5b) to Distal Mouse Chromosome 4 and Its Exclusion as a Candidate Gene for dysgenetic lens. / Jänne, Pasi A.; Rochelle, Julie M.; Martin-DeLeon, Patricia A.; Stambolian, Dwight; Seldin, Michael F; Nussbaum, Robert L.
In: Genomics, Vol. 28, No. 2, 20.07.1995, p. 280-285.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mapping of the 75-kDa Inositol Polyphosphate-5-Phosphatase (Inpp5b) to Distal Mouse Chromosome 4 and Its Exclusion as a Candidate Gene for dysgenetic lens
AU - Jänne, Pasi A.
AU - Rochelle, Julie M.
AU - Martin-DeLeon, Patricia A.
AU - Stambolian, Dwight
AU - Seldin, Michael F
AU - Nussbaum, Robert L.
PY - 1995/7/20
Y1 - 1995/7/20
N2 - We have determined the chromosomal localization of the murine gene encoding a 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b). Using two independent approaches, fluorescence in situ hybridization and interspecific backcross analysis, we show that Inpp5b maps to distal mouse Chromosome 4. This map position is within the conserved linkage group corresponding to the short arm of human Chromosome 1, where the human homologue, INPP5B, has been shown to map previously. The position of Inpp5b on amuse Chromosome 4 is in the vicinity of the mouse developmental mutation dysgenetic lens (dyl). However, using a genetic approach, we show that Inpp5b maps distal to dyl on mouse Chromosome 4.
AB - We have determined the chromosomal localization of the murine gene encoding a 75-kDa inositol polyphosphate-5-phosphatase (Inpp5b). Using two independent approaches, fluorescence in situ hybridization and interspecific backcross analysis, we show that Inpp5b maps to distal mouse Chromosome 4. This map position is within the conserved linkage group corresponding to the short arm of human Chromosome 1, where the human homologue, INPP5B, has been shown to map previously. The position of Inpp5b on amuse Chromosome 4 is in the vicinity of the mouse developmental mutation dysgenetic lens (dyl). However, using a genetic approach, we show that Inpp5b maps distal to dyl on mouse Chromosome 4.
UR - http://www.scopus.com/inward/record.url?scp=0029150107&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029150107&partnerID=8YFLogxK
U2 - 10.1006/geno.1995.1142
DO - 10.1006/geno.1995.1142
M3 - Article
C2 - 8530037
AN - SCOPUS:0029150107
VL - 28
SP - 280
EP - 285
JO - Genomics
JF - Genomics
SN - 0888-7543
IS - 2
ER -