Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with [14C]deoxyglucose

C. Kennedy, M. H. Des Rosiers, J. W. Jehle, M. Reivich, Frank R Sharp, L. Sokoloff

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Abstract

If sufficient time has elapsed following an intravenous pulse of [ 14C]deoxyglucose, the carbon-14 contents of the tissues of the central nervous system represent mainly the accumulated phosphorylated derivative of [14C]deoxyglucose and reflect the rates of glucose consumption of the tissues. Altered functional activity alters metabolic activity and the uptake of [14C]deoxyglucose in the tissues. By autoradiographic survey of sections of the central nervous system it is then possible to map all the regions with altered functional and metabolic activities in response to experimentally induced changes in functional state.

Original languageEnglish (US)
Pages (from-to)850-853
Number of pages4
JournalScience
Volume187
Issue number4179
StatePublished - 1975
Externally publishedYes

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    Kennedy, C., Des Rosiers, M. H., Jehle, J. W., Reivich, M., Sharp, F. R., & Sokoloff, L. (1975). Mapping of functional neural pathways by autoradiographic survey of local metabolic rate with [14C]deoxyglucose. Science, 187(4179), 850-853.