Abstract
The v-erb A oncogene represents a virally-transduced variant of a thyroid hormone receptor. Biochemical characterization of a series of mutant v-erh A proteins demonstrates that nuclear localization and DNA binding are both necessary for v-erb A function in the neoplastic cell and are mediated by multiple, overlapping domains within the v-erb A polypeptide. Domains of the v-erb A protein necessary for sequence-specific and sequenceindependent DNA binding are distinguishable from one another, and encompass sequences projecting beyond the zinc-finger motifs themselves. Although unable to bind T3 thyroid hormone, the remnants of the hormone binding domain continue to play unanticipated essential roles in v-erb A protein function.
Original language | English (US) |
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Pages (from-to) | 1303-1311 |
Number of pages | 9 |
Journal | Oncogene |
Volume | 5 |
Issue number | 9 |
State | Published - Sep 1990 |
ASJC Scopus subject areas
- Molecular Biology
- Cancer Research
- Genetics