Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter

William Sun, John Douglas Mcpherson, Danny Q. Hoang, John J. Wasmuth, Glen A. Evans, Mauricio Montal

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Degenerate DNA oligomers coding for highly conserved regions of the voltage-gated calcium channel were synthesized for the polymerase chain reaction (PCR) using DNA from a human brain cDNA library as template. PCR amplified a 640-bp DNA fragment from the human brain cDNA library. Sequencing revealed that this fragment encodes part of a protein highly homologous to a subtype of the dihydropyridine-sensitive calcium channel cloned from rabbit heart and rat brain. Southern analysis of panels of somatic cell hybrids mapped the 640-bp fragment, CACNL1A1, to human chromosome 12p13-pter.

Original languageEnglish (US)
Pages (from-to)1092-1094
Number of pages3
JournalGenomics
Volume14
Issue number4
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter'. Together they form a unique fingerprint.

  • Cite this