Mapping of 262 DNA markers into 24 intervals on human chromosome 11

Akira Tanigami, Takashi Tokino, Shuya Takiguchi, Masaki Mori, Thomas M Glaser, J. W. Park, Carol Jones, Yusuke Nakamura

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

We have extended our mapping effort on human chromosome 11 to encompass a total of 262 DNA markers, which have been mapped into 24 intervals on chromosome 11; 123 of the markers reveal RFLPs. These clones are scattered throughout the chromosome, although some clustering occurs in R-positive bands (p!5.1, p11.2, q13, and q23.3). Fifty-two of the markers were found to contain DNA sequences conserved in Chinese hamster, and some of these 52 also cross-hybridized with DNA from other mammals and/or chicken. As the length of chromosome 11 is estimated at nearly 130 cM, the average distance between RFLP markers is roughly 1 cM. The large panel of DNA markers on our map should contribute to investigations of hereditary diseases on this chromosome, and it will also provide reagents for constructing either fine-scale linkage and physical maps or contig maps of cosmids or yeast artificial chromosomes.

Original languageEnglish (US)
Pages (from-to)56-64
Number of pages9
JournalAmerican Journal of Human Genetics
Volume50
Issue number1
StatePublished - Jan 1992
Externally publishedYes

ASJC Scopus subject areas

  • Genetics

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