Mapping cortical thickness in children with 22q11.2 deletions

Carrie E. Bearden, Theo G M Van Erp, Rebecca A. Dutton, Helen Tran, Lara Zimmermann, Daqiang Sun, Jennifer A. Geaga, Tony J Simon, David C. Glahn, Tyrone D. Cannon, Beverly S. Emanuel, Arthur W. Toga, Paul M. Thompson

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The 22q11.2 deletion syndrome (velocardiofacial/DiGeorge syndrome, 22q11.2DS) involves cardiac and craniofacial anomalies, marked deficits in visuospatial cognition, and elevated rates of psychosis. Although the mechanism is unknown, characteristic brain alterations may predispose to development of psychosis and cognitive deficits in 22q11DS. We applied cortical pattern matching and new methods for measuring cortical thickness in millimeters to structural magnetic resonance images of 21 children with confirmed 22q11.2 deletions and 13 demographically matched healthy comparison subjects. Thickness was mapped at 65 536 homologous points, based on 3-dimensional distance from the cortical gray-white matter interface to the external gray-cerebrospinal fluid boundary. A pattern of regionally specific cortical thinning was observed in superior parietal cortices and right parietooccipital cortex, regions critical for visuospatial processing, and bilaterally in the most inferior portion of the inferior frontal gyrus (pars orbitalis), a key area for language development. Several of the 30 genes encoded in the deleted segment are highly expressed in the developing brain and known to affect early neuronal migration. These brain maps reveal how haploinsufficiency for such genes can affect cortical development and suggest a possible underlying pathophysiology of the neurobehavioral phenotype.

Original languageEnglish (US)
Pages (from-to)1889-1898
Number of pages10
JournalCerebral Cortex
Volume17
Issue number8
DOIs
StatePublished - Aug 2007

Fingerprint

DiGeorge Syndrome
Prefrontal Cortex
Psychotic Disorders
Brain
Haploinsufficiency
Parietal Lobe
Language Development
Cognition
Genes
Cerebrospinal Fluid
Healthy Volunteers
Magnetic Resonance Spectroscopy
Phenotype

Keywords

  • Brain mapping
  • Chromosome 22
  • Genetics
  • MRI
  • Velocardiofacial syndrome

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bearden, C. E., Van Erp, T. G. M., Dutton, R. A., Tran, H., Zimmermann, L., Sun, D., ... Thompson, P. M. (2007). Mapping cortical thickness in children with 22q11.2 deletions. Cerebral Cortex, 17(8), 1889-1898. https://doi.org/10.1093/cercor/bhl097

Mapping cortical thickness in children with 22q11.2 deletions. / Bearden, Carrie E.; Van Erp, Theo G M; Dutton, Rebecca A.; Tran, Helen; Zimmermann, Lara; Sun, Daqiang; Geaga, Jennifer A.; Simon, Tony J; Glahn, David C.; Cannon, Tyrone D.; Emanuel, Beverly S.; Toga, Arthur W.; Thompson, Paul M.

In: Cerebral Cortex, Vol. 17, No. 8, 08.2007, p. 1889-1898.

Research output: Contribution to journalArticle

Bearden, CE, Van Erp, TGM, Dutton, RA, Tran, H, Zimmermann, L, Sun, D, Geaga, JA, Simon, TJ, Glahn, DC, Cannon, TD, Emanuel, BS, Toga, AW & Thompson, PM 2007, 'Mapping cortical thickness in children with 22q11.2 deletions', Cerebral Cortex, vol. 17, no. 8, pp. 1889-1898. https://doi.org/10.1093/cercor/bhl097
Bearden CE, Van Erp TGM, Dutton RA, Tran H, Zimmermann L, Sun D et al. Mapping cortical thickness in children with 22q11.2 deletions. Cerebral Cortex. 2007 Aug;17(8):1889-1898. https://doi.org/10.1093/cercor/bhl097
Bearden, Carrie E. ; Van Erp, Theo G M ; Dutton, Rebecca A. ; Tran, Helen ; Zimmermann, Lara ; Sun, Daqiang ; Geaga, Jennifer A. ; Simon, Tony J ; Glahn, David C. ; Cannon, Tyrone D. ; Emanuel, Beverly S. ; Toga, Arthur W. ; Thompson, Paul M. / Mapping cortical thickness in children with 22q11.2 deletions. In: Cerebral Cortex. 2007 ; Vol. 17, No. 8. pp. 1889-1898.
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