Mandibular odontoameloblastoma in a rat and a horse

Brian G Murphy, Cynthia Bell, Amanda Koehne, Richard R. Dubielzig

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Odontoameloblastoma (OA) is a mixed odontogenic tumor that is an ameloblastoma with concurrent histologic evidence of odontoma differentiation. As a mixed tumor, OA is a tripartite lesion comprised of neoplastic odontogenic epithelium, induced dental ectomesenchyme (dental pulp), and mineralized dental matrix. Although rare, OA represents a diagnostic conundrum, as it is histologically closely related to 2 other mixed odontogenic tumors: odontoma (complex and compound) and ameloblastic fibro-odontoma. Herein we describe an OA arising from the mandible of a 4-mo-old Fischer 344 rat that had been exposed in utero to the mutagen ENU (N-ethyl-N-nitrosourea), and a naturally occurring lesion in a 2-y-old Appaloosa horse. In order to satisfy the diagnostic criteria for this lesion, mineralized dental matrix in relationship to neoplastic odontogenic epithelium must be identifiable within the OA lesion. This group of odontogenic tumors is differentiated by the degree to which the dental matrix is organized and the relative proportions of pulp ectomesenchyme, odontogenic matrix, and odontogenic epithelium.

Original languageEnglish (US)
Pages (from-to)536-540
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Volume29
Issue number4
DOIs
StatePublished - Jul 1 2017

Fingerprint

Odontoma
Odontogenic Tumors
lesions (animal)
Horses
Tooth
teeth
horses
epithelium
Epithelium
rats
Appaloosa
N-ethyl-N-nitrosourea
tooth pulp
Ethylnitrosourea
Ameloblastoma
Dental Pulp
Inbred F344 Rats
Mutagens
Mandible
pulp

Keywords

  • Equine
  • horses
  • mandible
  • odontoameloblastoma
  • odontogenic mixed tumor
  • rats

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Mandibular odontoameloblastoma in a rat and a horse. / Murphy, Brian G; Bell, Cynthia; Koehne, Amanda; Dubielzig, Richard R.

In: Journal of Veterinary Diagnostic Investigation, Vol. 29, No. 4, 01.07.2017, p. 536-540.

Research output: Contribution to journalArticle

Murphy, Brian G ; Bell, Cynthia ; Koehne, Amanda ; Dubielzig, Richard R. / Mandibular odontoameloblastoma in a rat and a horse. In: Journal of Veterinary Diagnostic Investigation. 2017 ; Vol. 29, No. 4. pp. 536-540.
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