Managing and analysing data from a large-scale study on Framingham Offspring relating brain structure to cognitive function

Joseph M. Massaro, Ralph B. D'Agostino, Lisa M. Sullivan, Alexa Beiser, Charles DeCarli, Rhoda Au, Merrill F. Elias, Philip A. Wolf

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

At the Framingham Heart Study under separate research grant funding from the National Institute of Aging, NIH, we are gathering brain structure and cognitive information on the Framingham Offspring, creating one of the largest known data sets to assess changes in brain structure associated with normative ageing and cognitive decline. Subject recruitment, data collection, data management and statistical analysis require a collaborative integrated effort on the part of the Framingham project team. Here we describe this effort, as well as the various brain structure and cognitive function parameters we are now collecting. We are currently performing analyses of data collected through 2002, and we discuss the statistical issues arising relating brain structure parameters to cognitive function.

Original languageEnglish (US)
Pages (from-to)351-367
Number of pages17
JournalStatistics in Medicine
Volume23
Issue number2
DOIs
StatePublished - Jan 30 2004

ASJC Scopus subject areas

  • Epidemiology

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