Management of mixed arterial venous lower extremity ulceration: A review

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16 Scopus citations


Mixed arterial venous disease is estimated to affect up to 26% of patients with lower extremity ulcerations. However, its clinical significance and pathophysiology are incompletely understood. Furthermore, there is no consensus on the optimal treatment modality, whether conservative or operative. In this review paper, we describe the current understanding of the pathophysiology of mixed arterial venous lower extremity ulcers. Guidelines for diagnostic tests for patients with mixed arterial venous diseases are discussed. We review some of the newer biological skin substitutes for conservative wound care. Finally, we propose a treatment algorithm based on current available data.

Original languageEnglish (US)
Pages (from-to)479-486
Number of pages8
JournalVascular Medicine (United Kingdom)
Issue number5
StatePublished - Oct 1 2015


  • arterial occlusive diseases
  • peripheral artery disease
  • ulcer
  • venous insufficiency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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