Management of hypertriglyceridemia in the diabetic patient

Ishwarlal Jialal, William Amess, Manpreet Kaur

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The hypertriglyceridemia of diabetes can be classified into mild to moderate (triglycerides between 150-499 mg/dL) and severe hypertriglyceridemia (triglycerides ≥500 mg/dL). As in any other individuals with hypertriglyceridemia, secondary causes need to be excluded. The management of severe hypertriglyceridemia (chylomicronemia syndrome) includes aggressive reduction of triglycerides with intravenous insulin, fibrates, omega-3 fatty acids, and/or niacin therapy to avert the risk of pancreatitis. In patients with mild to moderate hypertriglyceridemia, the treatment of choice is statin therapy to achieve the lowdensity lipoprotein (LDL) and non-high-density lipoprotein (HDL) target goals. The evidence base would favor niacin therapy in combination with statin therapy to achieve the goals pertaining to LDL cholesterol and non-HDL cholesterol. The data about the combination of fibrate therapy with statin therapy are disappointing.

Original languageEnglish (US)
Pages (from-to)316-320
Number of pages5
JournalCurrent Diabetes Reports
Volume10
Issue number4
DOIs
StatePublished - Aug 2010

Fingerprint

Hypertriglyceridemia
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Fibric Acids
Triglycerides
Niacin
Therapeutics
Omega-3 Fatty Acids
HDL Lipoproteins
Pancreatitis
HDL Cholesterol
Lipoproteins
Insulin

Keywords

  • Diabetes
  • Dyslipidemia
  • Fibrates
  • Hypertriglyceridemia
  • Niacin
  • Statins

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Management of hypertriglyceridemia in the diabetic patient. / Jialal, Ishwarlal; Amess, William; Kaur, Manpreet.

In: Current Diabetes Reports, Vol. 10, No. 4, 08.2010, p. 316-320.

Research output: Contribution to journalArticle

Jialal, Ishwarlal ; Amess, William ; Kaur, Manpreet. / Management of hypertriglyceridemia in the diabetic patient. In: Current Diabetes Reports. 2010 ; Vol. 10, No. 4. pp. 316-320.
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