Management of hypertension controls postoperative neurologic disorders after renal transplantation in cats

Andrew E. Kyles, Clare R. Gregory, John D. Wooldridge, Kyle G. Mathews, Lillian R. Aronson, Lynda Bernsteen, Jan Ilkiw

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Objectives - To determine the prevalence and describe the management of hypertension and central nervous system (CNS) complications after renal transplantation in cats. We also compared the prevalence of CNS complications between cats monitored and treated for postoperative hypertension and a previously described, historical control group of cats not monitored or treated for postoperative hypertension. Study Design - Retrospective clinical study. Animals or Sample Population - A total of 34 client-owned cats that received renal allografts for the treatment of end-stage renal failure. Methods - Medical records were reviewed. Data obtained included preoperative and postoperative systolic blood pressures, antihypertensive therapy, response to treatment, neurologic signs, and clinical outcome. The results were compared with a historical control group of feline renal allograft recipients that were neither monitored nor treated for postoperative hypertension. Results - Severe postoperative hypertension occurred in 21 of 34 of cats. Hypertension was treated in all 21 cats with subcutaneously administered hydralazine which reduced systolic blood pressure to less than 170 mm Hg in 15 minutes in 20 of 21 cats; hydralazine produced hypotension in one cat and failed to control hypertension in 1 cat. After transplantation, seizures were observed in one cat and other neurologic complications (stupor, ataxia, and central blindness) were observed in three cats. The prevalence of seizures and neurologic complication-related deaths after transplantation was significantly reduced with treatment of postoperative hypertension. Conclusions and Clinical Relevance - Hypertension is a major contributing factor to postoperative seizure activity after renal transplantation in cats; treatment of hypertension reduces the frequency of neurologic complications.

Original languageEnglish (US)
Pages (from-to)436-441
Number of pages6
JournalVeterinary Surgery
Volume28
Issue number6
StatePublished - Nov 1999

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kidney transplant
nervous system diseases
Nervous System Diseases
Kidney Transplantation
hypertension
Cats
cats
Hypertension
nervous system
seizures
Nervous System
Blood Pressure
Hydralazine
Seizures
allografting
systolic blood pressure
Allografts
central nervous system
Central Nervous System
Transplantation

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Kyles, A. E., Gregory, C. R., Wooldridge, J. D., Mathews, K. G., Aronson, L. R., Bernsteen, L., & Ilkiw, J. (1999). Management of hypertension controls postoperative neurologic disorders after renal transplantation in cats. Veterinary Surgery, 28(6), 436-441.

Management of hypertension controls postoperative neurologic disorders after renal transplantation in cats. / Kyles, Andrew E.; Gregory, Clare R.; Wooldridge, John D.; Mathews, Kyle G.; Aronson, Lillian R.; Bernsteen, Lynda; Ilkiw, Jan.

In: Veterinary Surgery, Vol. 28, No. 6, 11.1999, p. 436-441.

Research output: Contribution to journalArticle

Kyles, AE, Gregory, CR, Wooldridge, JD, Mathews, KG, Aronson, LR, Bernsteen, L & Ilkiw, J 1999, 'Management of hypertension controls postoperative neurologic disorders after renal transplantation in cats', Veterinary Surgery, vol. 28, no. 6, pp. 436-441.
Kyles AE, Gregory CR, Wooldridge JD, Mathews KG, Aronson LR, Bernsteen L et al. Management of hypertension controls postoperative neurologic disorders after renal transplantation in cats. Veterinary Surgery. 1999 Nov;28(6):436-441.
Kyles, Andrew E. ; Gregory, Clare R. ; Wooldridge, John D. ; Mathews, Kyle G. ; Aronson, Lillian R. ; Bernsteen, Lynda ; Ilkiw, Jan. / Management of hypertension controls postoperative neurologic disorders after renal transplantation in cats. In: Veterinary Surgery. 1999 ; Vol. 28, No. 6. pp. 436-441.
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