Management and Novel Adjuncts of Necrotizing Soft Tissue Infections

Christine S Cocanour, Phillip Chang, Jared M. Huston, Charles A. Adams, Jose J. Diaz, Charles B. Wessel, Bonnie A. Falcione, Graciela M. Bauza, Raquel A. Forsythe, Matthew R. Rosengart

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Necrotizing soft tissue infections (NSTI) have been recognized for millennia and continue to impose considerable burden on both patient and society in terms of morbidity, death, and the allocation of resources. With improvements in the delivery of critical care, outcomes have improved, although disease-specific therapies are lacking. The basic principles of early diagnosis, of prompt and broad antimicrobial therapy, and of aggressive debridement have remained unchanged. Clearly novel and new therapeutics are needed to combat this persistently lethal disease. This review emphasizes the pillars of NSTI management and then summarizes the contemporary evidence supporting the incorporation of novel adjuncts to the pharmacologic and operative foundations of managing this disease.

Original languageEnglish (US)
Pages (from-to)250-272
Number of pages23
JournalSurgical Infections
Issue number3
StatePublished - Apr 1 2017
Externally publishedYes


  • necrotizing fasciitis
  • necrotizing soft tissue infection
  • sepsis

ASJC Scopus subject areas

  • Surgery
  • Microbiology (medical)
  • Infectious Diseases


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