Mammographic density in a multiethnic cohort

Laurel A. Habel, Angela M. Capra, Nina Oestreicher, Gail A. Greendale, Jane A. Cauley, Joyce Bromberger, Carolyn J. Crandall, Ellen B Gold, Francesmary Modugno, Martine Salane, Charles Quesenberry, Barbara Sternfeld

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

OBJECTIVES: To compare mammographic density among premenopausal and early perimenopausal women from four racial/ethnic groups and to examine density and acculturation among Japanese and Chinese women. DESIGN: The study included 391 white, 60 African American, 171 Japanese, and 179 Chinese participants in the Study of Women's Health Across the Nation, a multisite study of US women transitioning through menopause. Mammograms done when women were premenopausal or early perimenopausal were assessed for area of dense breast tissue and the percent of the breast occupied by dense tissue (percent density). Information on race/ethnicity, acculturation, and other factors was obtained from standardized instruments. Multiple linear regression modeling was used to examine the association between race/ethnicity or acculturation and density measures. RESULTS: Age-adjusted mean percent density was highest for Chinese (52%) and lowest for African American (34%) women. After additional adjustment for body mass index, menopause status, age at first birth, breast-feeding duration, waist circumference, and smoking, African Americans had the highest mean percent density (51%) and Japanese women had the lowest (39%). In contrast, the area of dense tissue was highest for African Americans and similar for white, Japanese, and Chinese women. Less acculturated Chinese and Japanese women tended to have a larger area of density and a higher percent density. CONCLUSIONS: Neither the age-adjusted nor fully adjusted results for percent density or area of dense tissue reflected current differences in breast cancer incidence rates among similarly aged African American, Japanese, Chinese, and white women. In addition, mammographic density was higher in less acculturated Asian women.

Original languageEnglish (US)
Pages (from-to)891-899
Number of pages9
JournalMenopause
Volume14
Issue number5
DOIs
StatePublished - Sep 2007
Externally publishedYes

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African Americans
Acculturation
Menopause
Breast
Breast Density
Birth Order
Waist Circumference
Women's Health
Breast Feeding
Ethnic Groups
Linear Models
Body Mass Index
Smoking
Breast Neoplasms
Incidence

Keywords

  • Acculturation
  • Ethnicity
  • Mammographic density
  • Premenopause
  • Race

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Habel, L. A., Capra, A. M., Oestreicher, N., Greendale, G. A., Cauley, J. A., Bromberger, J., ... Sternfeld, B. (2007). Mammographic density in a multiethnic cohort. Menopause, 14(5), 891-899. https://doi.org/10.1097/gme.0b013e318032569c

Mammographic density in a multiethnic cohort. / Habel, Laurel A.; Capra, Angela M.; Oestreicher, Nina; Greendale, Gail A.; Cauley, Jane A.; Bromberger, Joyce; Crandall, Carolyn J.; Gold, Ellen B; Modugno, Francesmary; Salane, Martine; Quesenberry, Charles; Sternfeld, Barbara.

In: Menopause, Vol. 14, No. 5, 09.2007, p. 891-899.

Research output: Contribution to journalArticle

Habel, LA, Capra, AM, Oestreicher, N, Greendale, GA, Cauley, JA, Bromberger, J, Crandall, CJ, Gold, EB, Modugno, F, Salane, M, Quesenberry, C & Sternfeld, B 2007, 'Mammographic density in a multiethnic cohort', Menopause, vol. 14, no. 5, pp. 891-899. https://doi.org/10.1097/gme.0b013e318032569c
Habel LA, Capra AM, Oestreicher N, Greendale GA, Cauley JA, Bromberger J et al. Mammographic density in a multiethnic cohort. Menopause. 2007 Sep;14(5):891-899. https://doi.org/10.1097/gme.0b013e318032569c
Habel, Laurel A. ; Capra, Angela M. ; Oestreicher, Nina ; Greendale, Gail A. ; Cauley, Jane A. ; Bromberger, Joyce ; Crandall, Carolyn J. ; Gold, Ellen B ; Modugno, Francesmary ; Salane, Martine ; Quesenberry, Charles ; Sternfeld, Barbara. / Mammographic density in a multiethnic cohort. In: Menopause. 2007 ; Vol. 14, No. 5. pp. 891-899.
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abstract = "OBJECTIVES: To compare mammographic density among premenopausal and early perimenopausal women from four racial/ethnic groups and to examine density and acculturation among Japanese and Chinese women. DESIGN: The study included 391 white, 60 African American, 171 Japanese, and 179 Chinese participants in the Study of Women's Health Across the Nation, a multisite study of US women transitioning through menopause. Mammograms done when women were premenopausal or early perimenopausal were assessed for area of dense breast tissue and the percent of the breast occupied by dense tissue (percent density). Information on race/ethnicity, acculturation, and other factors was obtained from standardized instruments. Multiple linear regression modeling was used to examine the association between race/ethnicity or acculturation and density measures. RESULTS: Age-adjusted mean percent density was highest for Chinese (52{\%}) and lowest for African American (34{\%}) women. After additional adjustment for body mass index, menopause status, age at first birth, breast-feeding duration, waist circumference, and smoking, African Americans had the highest mean percent density (51{\%}) and Japanese women had the lowest (39{\%}). In contrast, the area of dense tissue was highest for African Americans and similar for white, Japanese, and Chinese women. Less acculturated Chinese and Japanese women tended to have a larger area of density and a higher percent density. CONCLUSIONS: Neither the age-adjusted nor fully adjusted results for percent density or area of dense tissue reflected current differences in breast cancer incidence rates among similarly aged African American, Japanese, Chinese, and white women. In addition, mammographic density was higher in less acculturated Asian women.",
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AU - Bromberger, Joyce

AU - Crandall, Carolyn J.

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AU - Quesenberry, Charles

AU - Sternfeld, Barbara

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N2 - OBJECTIVES: To compare mammographic density among premenopausal and early perimenopausal women from four racial/ethnic groups and to examine density and acculturation among Japanese and Chinese women. DESIGN: The study included 391 white, 60 African American, 171 Japanese, and 179 Chinese participants in the Study of Women's Health Across the Nation, a multisite study of US women transitioning through menopause. Mammograms done when women were premenopausal or early perimenopausal were assessed for area of dense breast tissue and the percent of the breast occupied by dense tissue (percent density). Information on race/ethnicity, acculturation, and other factors was obtained from standardized instruments. Multiple linear regression modeling was used to examine the association between race/ethnicity or acculturation and density measures. RESULTS: Age-adjusted mean percent density was highest for Chinese (52%) and lowest for African American (34%) women. After additional adjustment for body mass index, menopause status, age at first birth, breast-feeding duration, waist circumference, and smoking, African Americans had the highest mean percent density (51%) and Japanese women had the lowest (39%). In contrast, the area of dense tissue was highest for African Americans and similar for white, Japanese, and Chinese women. Less acculturated Chinese and Japanese women tended to have a larger area of density and a higher percent density. CONCLUSIONS: Neither the age-adjusted nor fully adjusted results for percent density or area of dense tissue reflected current differences in breast cancer incidence rates among similarly aged African American, Japanese, Chinese, and white women. In addition, mammographic density was higher in less acculturated Asian women.

AB - OBJECTIVES: To compare mammographic density among premenopausal and early perimenopausal women from four racial/ethnic groups and to examine density and acculturation among Japanese and Chinese women. DESIGN: The study included 391 white, 60 African American, 171 Japanese, and 179 Chinese participants in the Study of Women's Health Across the Nation, a multisite study of US women transitioning through menopause. Mammograms done when women were premenopausal or early perimenopausal were assessed for area of dense breast tissue and the percent of the breast occupied by dense tissue (percent density). Information on race/ethnicity, acculturation, and other factors was obtained from standardized instruments. Multiple linear regression modeling was used to examine the association between race/ethnicity or acculturation and density measures. RESULTS: Age-adjusted mean percent density was highest for Chinese (52%) and lowest for African American (34%) women. After additional adjustment for body mass index, menopause status, age at first birth, breast-feeding duration, waist circumference, and smoking, African Americans had the highest mean percent density (51%) and Japanese women had the lowest (39%). In contrast, the area of dense tissue was highest for African Americans and similar for white, Japanese, and Chinese women. Less acculturated Chinese and Japanese women tended to have a larger area of density and a higher percent density. CONCLUSIONS: Neither the age-adjusted nor fully adjusted results for percent density or area of dense tissue reflected current differences in breast cancer incidence rates among similarly aged African American, Japanese, Chinese, and white women. In addition, mammographic density was higher in less acculturated Asian women.

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KW - Race

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