Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world

R. Saif, A. R. Awan, Leslie A Lyons, B. Gandolfi, M. Tayyab, M. Ellahi Babar, M. Wasim

Research output: Contribution to journalArticle

Abstract

Current research highlights the Hspbl based screening of eight cat populations of the world to investigate the association of newly found locus within cat mammary tumors. Total 180 cats were screened on the basis of Hspbl 4 bp deletion locus (1514- 1517del4) which was observed in six mammary tumor cases in Siamese cat breed. Case-control association study revealed the non¬significance with P=0.201 and an overall mutant allele frequency of 0.30 ranging from 0.20-0.40 was observed in other cat populations. Similarly, HWE was also obeyed in combined population samples with P=0.860 and found non-significant with range of 0.429-0.708 in other non-Pakistani cat populations as well. These results might be helpful to understand the association of this novel locus in a better way with large sample size of cases and may also serve as a potential marker for mammary tumor diagnosis, particularly in cats and generally in all other animal populations in comparative genetics and genomics context.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalIranian Journal of Veterinary Research
Volume17
Issue number4
StatePublished - 2016
Externally publishedYes

Fingerprint

mammary neoplasms (animal)
Cats
cats
Breast Neoplasms
screening
mutation
Mutation
Population
loci
gene frequency
Genomics
Gene Frequency
Sample Size
Case-Control Studies
genomics
sampling
mutants
Research
animals

Keywords

  • Cat mammary lesions
  • Cat population
  • Felis catus
  • Hsp27 mutation
  • Hspbl screening

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Saif, R., Awan, A. R., Lyons, L. A., Gandolfi, B., Tayyab, M., Ellahi Babar, M., & Wasim, M. (2016). Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world. Iranian Journal of Veterinary Research, 17(4), 231-236.

Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world. / Saif, R.; Awan, A. R.; Lyons, Leslie A; Gandolfi, B.; Tayyab, M.; Ellahi Babar, M.; Wasim, M.

In: Iranian Journal of Veterinary Research, Vol. 17, No. 4, 2016, p. 231-236.

Research output: Contribution to journalArticle

Saif, R, Awan, AR, Lyons, LA, Gandolfi, B, Tayyab, M, Ellahi Babar, M & Wasim, M 2016, 'Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world', Iranian Journal of Veterinary Research, vol. 17, no. 4, pp. 231-236.
Saif, R. ; Awan, A. R. ; Lyons, Leslie A ; Gandolfi, B. ; Tayyab, M. ; Ellahi Babar, M. ; Wasim, M. / Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world. In: Iranian Journal of Veterinary Research. 2016 ; Vol. 17, No. 4. pp. 231-236.
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