Abstract
Current research highlights the Hspbl based screening of eight cat populations of the world to investigate the association of newly found locus within cat mammary tumors. Total 180 cats were screened on the basis of Hspbl 4 bp deletion locus (1514- 1517del4) which was observed in six mammary tumor cases in Siamese cat breed. Case-control association study revealed the non¬significance with P=0.201 and an overall mutant allele frequency of 0.30 ranging from 0.20-0.40 was observed in other cat populations. Similarly, HWE was also obeyed in combined population samples with P=0.860 and found non-significant with range of 0.429-0.708 in other non-Pakistani cat populations as well. These results might be helpful to understand the association of this novel locus in a better way with large sample size of cases and may also serve as a potential marker for mammary tumor diagnosis, particularly in cats and generally in all other animal populations in comparative genetics and genomics context.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 231-236 |
| Number of pages | 6 |
| Journal | Iranian Journal of Veterinary Research |
| Volume | 17 |
| Issue number | 4 |
| State | Published - 2016 |
| Externally published | Yes |
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Keywords
- Cat mammary lesions
- Cat population
- Felis catus
- Hsp27 mutation
- Hspbl screening
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world. / Saif, R.; Awan, A. R.; Lyons, Leslie A; Gandolfi, B.; Tayyab, M.; Ellahi Babar, M.; Wasim, M.
In: Iranian Journal of Veterinary Research, Vol. 17, No. 4, 2016, p. 231-236.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mammary tumor associated Hspb1 mutation and screening of eight cat populations of the world
AU - Saif, R.
AU - Awan, A. R.
AU - Lyons, Leslie A
AU - Gandolfi, B.
AU - Tayyab, M.
AU - Ellahi Babar, M.
AU - Wasim, M.
PY - 2016
Y1 - 2016
N2 - Current research highlights the Hspbl based screening of eight cat populations of the world to investigate the association of newly found locus within cat mammary tumors. Total 180 cats were screened on the basis of Hspbl 4 bp deletion locus (1514- 1517del4) which was observed in six mammary tumor cases in Siamese cat breed. Case-control association study revealed the non¬significance with P=0.201 and an overall mutant allele frequency of 0.30 ranging from 0.20-0.40 was observed in other cat populations. Similarly, HWE was also obeyed in combined population samples with P=0.860 and found non-significant with range of 0.429-0.708 in other non-Pakistani cat populations as well. These results might be helpful to understand the association of this novel locus in a better way with large sample size of cases and may also serve as a potential marker for mammary tumor diagnosis, particularly in cats and generally in all other animal populations in comparative genetics and genomics context.
AB - Current research highlights the Hspbl based screening of eight cat populations of the world to investigate the association of newly found locus within cat mammary tumors. Total 180 cats were screened on the basis of Hspbl 4 bp deletion locus (1514- 1517del4) which was observed in six mammary tumor cases in Siamese cat breed. Case-control association study revealed the non¬significance with P=0.201 and an overall mutant allele frequency of 0.30 ranging from 0.20-0.40 was observed in other cat populations. Similarly, HWE was also obeyed in combined population samples with P=0.860 and found non-significant with range of 0.429-0.708 in other non-Pakistani cat populations as well. These results might be helpful to understand the association of this novel locus in a better way with large sample size of cases and may also serve as a potential marker for mammary tumor diagnosis, particularly in cats and generally in all other animal populations in comparative genetics and genomics context.
KW - Cat mammary lesions
KW - Cat population
KW - Felis catus
KW - Hsp27 mutation
KW - Hspbl screening
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UR - http://www.scopus.com/inward/citedby.url?scp=85010508369&partnerID=8YFLogxK
M3 - Article
VL - 17
SP - 231
EP - 236
JO - Iranian Journal of Veterinary Research
JF - Iranian Journal of Veterinary Research
SN - 1728-1997
IS - 4
ER -