Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

Timothy C. Wang, Robert Cardiff, Lawrence Zukerberg, Emma Lees, Andrew Arnold, Emmett V. Schmidt

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Abstract

Physical associations between cyclins, viral oncogenes and tumour suppressor genes imply a central role for cyclins in growth control 1, 2. Cyclin D1 was identified as a candidate oncogene (PRAD1) in tumour-specific DNA rearrangements3, 4. and is suspected to be a contributor to several types of neoplasms including breast cancer 5, 6. Cyclin D1 also rescues G1 cyclin-defective Saccharomyces cerevisiae 7, and is a growth-regulated gene8. Despite evidence suggesting that cyclin D1 is an oncogene, its ability to transform cells directly in culture remains controversial9-16. To evaluate its potential to deregulate growth in vivo in a physiologically relevant tissue we overexpressed cyclin Dl in mammary cells in transgenic mice. We report here that overexpression of cyclin Dl resulted in abnormal mammary cell proliferation including the development of mammary adenocarcinomas. We conclude that overexpression of cyclin Dl deregulates cell proliferation and can induce tumorigenic changes in mammary tissues, suggesting that cyclin Dl indeed plays an important oncogenic role in breast cancer.

Original languageEnglish (US)
Pages (from-to)669-671
Number of pages3
JournalNature
Volume369
Issue number6482
DOIs
StatePublished - Jan 1 1994

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Cyclins
Cyclin D1
Transgenic Mice
Hyperplasia
Breast Neoplasms
Breast
Oncogenes
Growth
Cyclin G1
Cell Proliferation
Tumor Suppressor Genes
Saccharomyces cerevisiae
Neoplasms
Adenocarcinoma
DNA

ASJC Scopus subject areas

  • General

Cite this

Wang, T. C., Cardiff, R., Zukerberg, L., Lees, E., Arnold, A., & Schmidt, E. V. (1994). Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature, 369(6482), 669-671. https://doi.org/10.1038/369669a0

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. / Wang, Timothy C.; Cardiff, Robert; Zukerberg, Lawrence; Lees, Emma; Arnold, Andrew; Schmidt, Emmett V.

In: Nature, Vol. 369, No. 6482, 01.01.1994, p. 669-671.

Research output: Contribution to journalArticle

Wang, TC, Cardiff, R, Zukerberg, L, Lees, E, Arnold, A & Schmidt, EV 1994, 'Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice', Nature, vol. 369, no. 6482, pp. 669-671. https://doi.org/10.1038/369669a0
Wang TC, Cardiff R, Zukerberg L, Lees E, Arnold A, Schmidt EV. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature. 1994 Jan 1;369(6482):669-671. https://doi.org/10.1038/369669a0
Wang, Timothy C. ; Cardiff, Robert ; Zukerberg, Lawrence ; Lees, Emma ; Arnold, Andrew ; Schmidt, Emmett V. / Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. In: Nature. 1994 ; Vol. 369, No. 6482. pp. 669-671.
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