Mammalian transforming growth factor β1 activated after ingestion by Anopheles stephensi modulates mosquito immunity

Shirley Luckhart, Andrea L. Crampton, Ruben Zamora, Matthew J. Lieber, Patricia C. Dos Santos, Tina M L Peterson, Nicole Emmith, Junghwa Lim, David A. Wink, Yoram Vodovotz

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

During the process of bloodfeeding by Anopheles stephensi, mammalian latent transforming growth factor β1 (TGF-β1) is ingested and activated rapidly in the mosquito midgut. Activation may involve heme and nitric oxide (NO), agents released in the midgut during blood digestion and catalysis of L-arginine oxidation by A. stephensi NO synthase (AsNOS). Active TGF-β1 persists in the mosquito midgut to extended times postingestion and is recognized by mosquito cells as a cytokine. In a manner analogous to the regulation of vertebrate inducible NO synthase and malaria parasite (Plasmodium) infection in mammals by TGF-β1, TGF-β1 regulates AsNOS expression and Plasmodium development in A. stephensi. Together, these observations indicate that, through conserved immunological cross talk, mammalian and mosquito immune systems interface with each other to influence the cycle of Plasmodium development.

Original languageEnglish (US)
Pages (from-to)3000-3009
Number of pages10
JournalInfection and Immunity
Volume71
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

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Anopheles
Transforming Growth Factors
Culicidae
Immunity
Eating
Plasmodium
Nitric Oxide Synthase
Malaria
Parasitic Diseases
Nitric Oxide Synthase Type II
Catalysis
Heme
Arginine
Vertebrates
Digestion
Mammals
Immune System
Nitric Oxide
Cytokines

ASJC Scopus subject areas

  • Immunology

Cite this

Luckhart, S., Crampton, A. L., Zamora, R., Lieber, M. J., Dos Santos, P. C., Peterson, T. M. L., ... Vodovotz, Y. (2003). Mammalian transforming growth factor β1 activated after ingestion by Anopheles stephensi modulates mosquito immunity. Infection and Immunity, 71(6), 3000-3009. https://doi.org/10.1128/IAI.71.6.3000-3009.2003

Mammalian transforming growth factor β1 activated after ingestion by Anopheles stephensi modulates mosquito immunity. / Luckhart, Shirley; Crampton, Andrea L.; Zamora, Ruben; Lieber, Matthew J.; Dos Santos, Patricia C.; Peterson, Tina M L; Emmith, Nicole; Lim, Junghwa; Wink, David A.; Vodovotz, Yoram.

In: Infection and Immunity, Vol. 71, No. 6, 01.06.2003, p. 3000-3009.

Research output: Contribution to journalArticle

Luckhart, S, Crampton, AL, Zamora, R, Lieber, MJ, Dos Santos, PC, Peterson, TML, Emmith, N, Lim, J, Wink, DA & Vodovotz, Y 2003, 'Mammalian transforming growth factor β1 activated after ingestion by Anopheles stephensi modulates mosquito immunity', Infection and Immunity, vol. 71, no. 6, pp. 3000-3009. https://doi.org/10.1128/IAI.71.6.3000-3009.2003
Luckhart, Shirley ; Crampton, Andrea L. ; Zamora, Ruben ; Lieber, Matthew J. ; Dos Santos, Patricia C. ; Peterson, Tina M L ; Emmith, Nicole ; Lim, Junghwa ; Wink, David A. ; Vodovotz, Yoram. / Mammalian transforming growth factor β1 activated after ingestion by Anopheles stephensi modulates mosquito immunity. In: Infection and Immunity. 2003 ; Vol. 71, No. 6. pp. 3000-3009.
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