Mammalian lactoferrin receptors: Structure and function

Y. A. Suzuki, V. Lopez, B. Lönnerdal

Research output: Contribution to journalArticle

234 Scopus citations

Abstract

Mammalian lactoferrin (Lf) receptors are suggested to have pivotal roles for mediating multiple functions of Lf. In this review, we focus on current knowledge of the structure and function of mammalian Lf receptors, mainly the first cloned Lf receptor that has been shown to be expressed in the infant small intestine at high levels but also in virtually all other tissues. The small intestinal Lf receptor takes up iron from Lf into cells and presumably exerts other physiological functions. Other Lf receptors in various tissues have also been reported to mediate some functions of Lf, such as modulating immune function, inhibiting platelet aggregation and enhancing collagen gel contractile strength. The detailed mechanisms behind the receptor-Lf interactions still need to be elucidated.

Original languageEnglish (US)
Pages (from-to)2560-2575
Number of pages16
JournalCellular and Molecular Life Sciences
Volume62
Issue number22
DOIs
StatePublished - Nov 2005

Keywords

  • Immune function
  • Iron metabolism
  • Lactoferrin
  • Lactoferrin receptor
  • Mammalian receptor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology

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