TY - JOUR
T1 - Malnutrition, poor post-natal growth, intestinal dysbiosis and the developing lung
AU - Underwood, Mark A.
AU - Lakshminrusimha, Satyan
AU - Steinhorn, Robin H
AU - Wedgwood, Stephen
N1 - Funding Information:
Acknowledgements This work is supported by the National Institutes of Health HD096241 (MAU), HD072929 (SL)
PY - 2020
Y1 - 2020
N2 - In extremely preterm infants, poor post-natal growth, intestinal dysbiosis and bronchopulmonary dysplasia are common, and each is associated with long-term complications. The central hypothesis that this review will address is that these three common conditions are interrelated. Challenges to studying this hypothesis include the understanding that malnutrition and poor post-natal growth are not synonymous and that there is not agreement on what constitutes a normal intestinal microbiota in this evolutionarily new population. If this hypothesis is supported, further study of whether “correcting” intestinal dysbiosis in extremely preterm infants reduces postnatal growth restriction and/or bronchopulmonary dysplasia is indicated.
AB - In extremely preterm infants, poor post-natal growth, intestinal dysbiosis and bronchopulmonary dysplasia are common, and each is associated with long-term complications. The central hypothesis that this review will address is that these three common conditions are interrelated. Challenges to studying this hypothesis include the understanding that malnutrition and poor post-natal growth are not synonymous and that there is not agreement on what constitutes a normal intestinal microbiota in this evolutionarily new population. If this hypothesis is supported, further study of whether “correcting” intestinal dysbiosis in extremely preterm infants reduces postnatal growth restriction and/or bronchopulmonary dysplasia is indicated.
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U2 - 10.1038/s41372-020-00858-x
DO - 10.1038/s41372-020-00858-x
M3 - Review article
AN - SCOPUS:85092506424
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
ER -