Malnutrition, poor post-natal growth, intestinal dysbiosis and the developing lung

Mark A. Underwood, Satyan Lakshminrusimha, Robin H Steinhorn, Stephen Wedgwood

Research output: Contribution to journalReview articlepeer-review

Abstract

In extremely preterm infants, poor post-natal growth, intestinal dysbiosis and bronchopulmonary dysplasia are common, and each is associated with long-term complications. The central hypothesis that this review will address is that these three common conditions are interrelated. Challenges to studying this hypothesis include the understanding that malnutrition and poor post-natal growth are not synonymous and that there is not agreement on what constitutes a normal intestinal microbiota in this evolutionarily new population. If this hypothesis is supported, further study of whether “correcting” intestinal dysbiosis in extremely preterm infants reduces postnatal growth restriction and/or bronchopulmonary dysplasia is indicated.

Original languageEnglish (US)
JournalJournal of Perinatology
DOIs
StateAccepted/In press - 2020

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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