Mallory body formation in hepatic nodules of mice ingesting dieldrin

E. F. Meierhenry, B. H. Ruebner, M. Eric Gershwin, L. S. Hsieh, S. W. French

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29 Scopus citations

Abstract

Mallory bodies (MBs) were observed in hepatic nodules induced by long-term administration of a diet containing 10 p.p.m. of dieldrin to C57BL/6 mice. MBs were first detected after 46 weeks and were seen in 26 of 41 mice which developed hepatic nodules. The MBs were limited to the nodules in 25 mice. Twenty-one of the nodules were carcinomas and 20 of those contained MBs. The observations suggest that MBs may be a marker for neoplastic transformation and may prove useful in experimental studies of carcinogenesis.

Original languageEnglish (US)
Pages (from-to)392-396
Number of pages5
JournalLaboratory Investigation
Volume44
Issue number4
StatePublished - 1981

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Meierhenry, E. F., Ruebner, B. H., Gershwin, M. E., Hsieh, L. S., & French, S. W. (1981). Mallory body formation in hepatic nodules of mice ingesting dieldrin. Laboratory Investigation, 44(4), 392-396.