Malignant histiocytosis in Bernese Mountain dogs.

A. Rosin, Peter F Moore, R. Dubielzig

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Malignant histiocytosis was diagnosed in 10 male and 1 female Bernese Mountain Dogs. Nine of these dogs were closely related. The disease was characterized by a rapidly progressive and inevitably fatal course. Clinical signs varied, but lethargy, anorexia, weight loss, and respiratory and CNS abnormalities predominated. The lungs were the primary site of tumor involvement in 10 dogs. The eleventh dog had lymphadenopathy and severe anemia. Metastatic lesions were detected in all dogs. Anaplastic pulmonary carcinoma was diagnosed originally in 6 of the 11 cases, but this diagnosis was changed to malignant histiocytosis after electron microscopic examination of tissues and immunohistochemical identification of histiocytic markers in the tumor cells.

Original languageEnglish (US)
Pages (from-to)1041-1045
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume188
Issue number9
StatePublished - May 1 1986

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histiocytosis
Histiocytic Sarcoma
mountains
Dogs
dogs
lungs
Lung
lymphatic diseases
Lethargy
Anorexia
Tumor Biomarkers
anorexia
lesions (animal)
anemia
carcinoma
Anemia
Weight Loss
weight loss
electrons
Electrons

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Malignant histiocytosis in Bernese Mountain dogs. / Rosin, A.; Moore, Peter F; Dubielzig, R.

In: Journal of the American Veterinary Medical Association, Vol. 188, No. 9, 01.05.1986, p. 1041-1045.

Research output: Contribution to journalArticle

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