Malignant histiocytosis in Bernese Mountain dogs.

A. Rosin, P. Moore, R. Dubielzig

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Malignant histiocytosis was diagnosed in 10 male and 1 female Bernese Mountain Dogs. Nine of these dogs were closely related. The disease was characterized by a rapidly progressive and inevitably fatal course. Clinical signs varied, but lethargy, anorexia, weight loss, and respiratory and CNS abnormalities predominated. The lungs were the primary site of tumor involvement in 10 dogs. The eleventh dog had lymphadenopathy and severe anemia. Metastatic lesions were detected in all dogs. Anaplastic pulmonary carcinoma was diagnosed originally in 6 of the 11 cases, but this diagnosis was changed to malignant histiocytosis after electron microscopic examination of tissues and immunohistochemical identification of histiocytic markers in the tumor cells.

Original languageEnglish (US)
Pages (from-to)1041-1045
Number of pages5
JournalJournal of the American Veterinary Medical Association
Issue number9
StatePublished - May 1 1986

ASJC Scopus subject areas

  • veterinary(all)


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