Male sex may not be associated with worse outcomes in primary all-posterior adult spinal deformity surgery: A multicenter analysis

for the International Spine Study Group

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE Adolescent spine deformity studies have shown that male patients require longer surgery and have greater estimated blood loss (EBL) and complications compared with female patients. No studies exist to support this relationship in adult spinal deformity (ASD). The purpose of this study was to investigate associations between sex and complications, deformity correction, and health-related quality of life (HRQOL) in patients with ASD. It was hypothesized that male ASD patients would have greater EBL, longer surgery, and more complications than female ASD patients. METHODS A multicenter ASD cohort was retrospectively queried for patients who underwent primary posterior-only instrumented fusions with a minimum of 5 levels fused. The minimum follow-up was 2 years. Primary outcomes were EBL, operative time, intra-, peri-, and postoperative complications, radiographic correction, and HRQOL outcomes (Oswestry Disability Index, SF-36, and Scoliosis Research Society-22r Questionnaire). Poisson multivariate regression was used to control for age, comorbidities, and levels fused. RESULTS Ninety male and 319 female patients met the inclusion criteria. Male patients had significantly greater mean EBL (2373 ml vs 1829 ml, p = 0.01). The mean operative time, transfusion requirements, and final radiographic measurements did not differ between sexes. Similarly, changes in HRQOL showed no significant differences. Finally, there were no sex differences in the incidence of complications (total, major, or minor) at any time point after controlling for age, body mass index, comorbidities, and levels fused. CONCLUSIONS Despite higher EBL, male ASD patients did not experience more complications or require less deformity correction at the 2-year follow-up. HRQOL scores similarly showed no sex differences. These findings differ from adolescent deformity studies, and surgeons can counsel patients that sex is unlikely to influence the outcomes and complication rates of primary all-posterior ASD surgery.

Original languageEnglish (US)
Article numberE9
JournalNeurosurgical Focus
Volume43
Issue number6
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

Fingerprint

Quality of Life
Operative Time
Sex Characteristics
Comorbidity
Scoliosis
Spine
Body Mass Index
Incidence
Research

Keywords

  • Adult spinal deformity
  • Blood loss
  • Complications
  • Deformity correction
  • Gender
  • Health-related quality of life
  • Patient-reported outcomes
  • Sex

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Male sex may not be associated with worse outcomes in primary all-posterior adult spinal deformity surgery : A multicenter analysis. / for the International Spine Study Group.

In: Neurosurgical Focus, Vol. 43, No. 6, E9, 01.12.2017.

Research output: Contribution to journalArticle

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title = "Male sex may not be associated with worse outcomes in primary all-posterior adult spinal deformity surgery: A multicenter analysis",
abstract = "OBJECTIVE Adolescent spine deformity studies have shown that male patients require longer surgery and have greater estimated blood loss (EBL) and complications compared with female patients. No studies exist to support this relationship in adult spinal deformity (ASD). The purpose of this study was to investigate associations between sex and complications, deformity correction, and health-related quality of life (HRQOL) in patients with ASD. It was hypothesized that male ASD patients would have greater EBL, longer surgery, and more complications than female ASD patients. METHODS A multicenter ASD cohort was retrospectively queried for patients who underwent primary posterior-only instrumented fusions with a minimum of 5 levels fused. The minimum follow-up was 2 years. Primary outcomes were EBL, operative time, intra-, peri-, and postoperative complications, radiographic correction, and HRQOL outcomes (Oswestry Disability Index, SF-36, and Scoliosis Research Society-22r Questionnaire). Poisson multivariate regression was used to control for age, comorbidities, and levels fused. RESULTS Ninety male and 319 female patients met the inclusion criteria. Male patients had significantly greater mean EBL (2373 ml vs 1829 ml, p = 0.01). The mean operative time, transfusion requirements, and final radiographic measurements did not differ between sexes. Similarly, changes in HRQOL showed no significant differences. Finally, there were no sex differences in the incidence of complications (total, major, or minor) at any time point after controlling for age, body mass index, comorbidities, and levels fused. CONCLUSIONS Despite higher EBL, male ASD patients did not experience more complications or require less deformity correction at the 2-year follow-up. HRQOL scores similarly showed no sex differences. These findings differ from adolescent deformity studies, and surgeons can counsel patients that sex is unlikely to influence the outcomes and complication rates of primary all-posterior ASD surgery.",
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author = "{for the International Spine Study Group} and Bumpass, {David B.} and Lenke, {Lawrence G.} and Gum, {Jeffrey L.} and Shaffrey, {Christopher I.} and Smith, {Justin S.} and Ames, {Christopher P.} and Shay Bess and Neuman, {Brian J.} and Klineberg, {Eric Otto} and Mundis, {Gregory M.} and Frank Schwab and Virginie Lafage and Kim, {Han Jo} and Burton, {Douglas C.} and Kebaish, {Khaled M.} and Richard Hostin and Renaud Lafage and Kelly, {Michael P.}",
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T2 - A multicenter analysis

AU - for the International Spine Study Group

AU - Bumpass, David B.

AU - Lenke, Lawrence G.

AU - Gum, Jeffrey L.

AU - Shaffrey, Christopher I.

AU - Smith, Justin S.

AU - Ames, Christopher P.

AU - Bess, Shay

AU - Neuman, Brian J.

AU - Klineberg, Eric Otto

AU - Mundis, Gregory M.

AU - Schwab, Frank

AU - Lafage, Virginie

AU - Kim, Han Jo

AU - Burton, Douglas C.

AU - Kebaish, Khaled M.

AU - Hostin, Richard

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N2 - OBJECTIVE Adolescent spine deformity studies have shown that male patients require longer surgery and have greater estimated blood loss (EBL) and complications compared with female patients. No studies exist to support this relationship in adult spinal deformity (ASD). The purpose of this study was to investigate associations between sex and complications, deformity correction, and health-related quality of life (HRQOL) in patients with ASD. It was hypothesized that male ASD patients would have greater EBL, longer surgery, and more complications than female ASD patients. METHODS A multicenter ASD cohort was retrospectively queried for patients who underwent primary posterior-only instrumented fusions with a minimum of 5 levels fused. The minimum follow-up was 2 years. Primary outcomes were EBL, operative time, intra-, peri-, and postoperative complications, radiographic correction, and HRQOL outcomes (Oswestry Disability Index, SF-36, and Scoliosis Research Society-22r Questionnaire). Poisson multivariate regression was used to control for age, comorbidities, and levels fused. RESULTS Ninety male and 319 female patients met the inclusion criteria. Male patients had significantly greater mean EBL (2373 ml vs 1829 ml, p = 0.01). The mean operative time, transfusion requirements, and final radiographic measurements did not differ between sexes. Similarly, changes in HRQOL showed no significant differences. Finally, there were no sex differences in the incidence of complications (total, major, or minor) at any time point after controlling for age, body mass index, comorbidities, and levels fused. CONCLUSIONS Despite higher EBL, male ASD patients did not experience more complications or require less deformity correction at the 2-year follow-up. HRQOL scores similarly showed no sex differences. These findings differ from adolescent deformity studies, and surgeons can counsel patients that sex is unlikely to influence the outcomes and complication rates of primary all-posterior ASD surgery.

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KW - Blood loss

KW - Complications

KW - Deformity correction

KW - Gender

KW - Health-related quality of life

KW - Patient-reported outcomes

KW - Sex

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