Maintenance bevacizumab is associated with increased hemoglobin in patients with advanced, nonsquamous, non-small cell lung cancer

Jonathan Riess; Aaron C. Logan; Yelena Krupitskaya; Sukhmani Padda; Christelle Clément-Duchne; Kristen Ganjoo; A. Dimitrios Colevas; Melanie San Pedro-Salcedo; Calvin J. Kuo; Heather A. Wakelee

doi:10.3109/07357907.2012.656862

Maintenance bevacizumab is associated with increased hemoglobin in patients with advanced, nonsquamous, non-small cell lung cancer

Jonathan Riess, Aaron C. Logan, Yelena Krupitskaya, Sukhmani Padda, Christelle Clément-Duchne, Kristen Ganjoo, A. Dimitrios Colevas, Melanie San Pedro-Salcedo, Calvin J. Kuo, Heather A. Wakelee

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We retrospectively analyzed hematologic parameters in 22 patients with advanced, nonsquamous, NSCLC undergoing VEGF inhibition on a phase II clinical trial of bevacizumab, carboplatin, and gemcitabine. We also examined TTP in relation to hemoglobin changes. Median hemoglobin increased significantly from a 12.9 g/dL pretreatment to 13.8 g/dL (p =.01) after the second cycle of maintenance bevacizumab until the first off cycle measurement. There was no difference in TTP in patients who achieved a rise in hemoglobin compared with patients who did not (median 238 days vs. 268 days, p =.38.) Maintenance bevacizumab is associated with increased hemoglobin in advanced, nonsquamous, NSCLC patients.

Original language	English (US)
Pages (from-to)	231-235
Number of pages	5
Journal	Cancer Investigation
Volume	30
Issue number	3
DOIs	https://doi.org/10.3109/07357907.2012.656862
State	Published - Mar 2012
Externally published	Yes

Keywords

Angiogenesis
Cancer biomarkers
Clinical trials
Non-small cell lung cancer
VEGF

ASJC Scopus subject areas

Cancer Research
Oncology

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Riess, J., Logan, A. C., Krupitskaya, Y., Padda, S., Clément-Duchne, C., Ganjoo, K., Colevas, A. D., Pedro-Salcedo, M. S., Kuo, C. J., & Wakelee, H. A. (2012). Maintenance bevacizumab is associated with increased hemoglobin in patients with advanced, nonsquamous, non-small cell lung cancer. Cancer Investigation, 30(3), 231-235. https://doi.org/10.3109/07357907.2012.656862

Maintenance bevacizumab is associated with increased hemoglobin in patients with advanced, nonsquamous, non-small cell lung cancer. / Riess, Jonathan; Logan, Aaron C.; Krupitskaya, Yelena; Padda, Sukhmani; Clément-Duchne, Christelle; Ganjoo, Kristen; Colevas, A. Dimitrios; Pedro-Salcedo, Melanie San; Kuo, Calvin J.; Wakelee, Heather A.

In: Cancer Investigation, Vol. 30, No. 3, 03.2012, p. 231-235.

Research output: Contribution to journal › Article › peer-review

Riess, Jonathan ; Logan, Aaron C. ; Krupitskaya, Yelena ; Padda, Sukhmani ; Clément-Duchne, Christelle ; Ganjoo, Kristen ; Colevas, A. Dimitrios ; Pedro-Salcedo, Melanie San ; Kuo, Calvin J. ; Wakelee, Heather A. / Maintenance bevacizumab is associated with increased hemoglobin in patients with advanced, nonsquamous, non-small cell lung cancer. In: Cancer Investigation. 2012 ; Vol. 30, No. 3. pp. 231-235.

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abstract = "We retrospectively analyzed hematologic parameters in 22 patients with advanced, nonsquamous, NSCLC undergoing VEGF inhibition on a phase II clinical trial of bevacizumab, carboplatin, and gemcitabine. We also examined TTP in relation to hemoglobin changes. Median hemoglobin increased significantly from a 12.9 g/dL pretreatment to 13.8 g/dL (p =.01) after the second cycle of maintenance bevacizumab until the first off cycle measurement. There was no difference in TTP in patients who achieved a rise in hemoglobin compared with patients who did not (median 238 days vs. 268 days, p =.38.) Maintenance bevacizumab is associated with increased hemoglobin in advanced, nonsquamous, NSCLC patients.",

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