Maintenance bevacizumab is associated with increased hemoglobin in patients with advanced, nonsquamous, non-small cell lung cancer

Jonathan Riess, Aaron C. Logan, Yelena Krupitskaya, Sukhmani Padda, Christelle Clément-Duchne, Kristen Ganjoo, A. Dimitrios Colevas, Melanie San Pedro-Salcedo, Calvin J. Kuo, Heather A. Wakelee

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

We retrospectively analyzed hematologic parameters in 22 patients with advanced, nonsquamous, NSCLC undergoing VEGF inhibition on a phase II clinical trial of bevacizumab, carboplatin, and gemcitabine. We also examined TTP in relation to hemoglobin changes. Median hemoglobin increased significantly from a 12.9 g/dL pretreatment to 13.8 g/dL (p =.01) after the second cycle of maintenance bevacizumab until the first off cycle measurement. There was no difference in TTP in patients who achieved a rise in hemoglobin compared with patients who did not (median 238 days vs. 268 days, p =.38.) Maintenance bevacizumab is associated with increased hemoglobin in advanced, nonsquamous, NSCLC patients.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalCancer Investigation
Volume30
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • Angiogenesis
  • Cancer biomarkers
  • Clinical trials
  • Non-small cell lung cancer
  • VEGF

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint Dive into the research topics of 'Maintenance bevacizumab is associated with increased hemoglobin in patients with advanced, nonsquamous, non-small cell lung cancer'. Together they form a unique fingerprint.

  • Cite this

    Riess, J., Logan, A. C., Krupitskaya, Y., Padda, S., Clément-Duchne, C., Ganjoo, K., Colevas, A. D., Pedro-Salcedo, M. S., Kuo, C. J., & Wakelee, H. A. (2012). Maintenance bevacizumab is associated with increased hemoglobin in patients with advanced, nonsquamous, non-small cell lung cancer. Cancer Investigation, 30(3), 231-235. https://doi.org/10.3109/07357907.2012.656862