Magnocellular and parvocellular visual pathways are both affected in a macaque monkey model of glaucoma

J. C. Vickers, P. R. Hof, R. A. Schumer, R. F. Wang, S. M. Podos, John Morrison

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Purpose: Neurochemical changes in nerve cells were investigated in the lateral geniculate nucleus (LGN) and primary visual cortex of macaque monkeys with experimentally induced glaucoma. Methods: Glaucomatous damage was induced in one eye of experimental animals by elevation of intraocular pressure following laser burns to the trabecular meshwork. Staining for the metabolic marker cytochrome oxidase, as well as immunolabelling for the neuronal markers synaptophysin and neurofilament proteins, was conducted on sections of the LGN and primary visual cortex. Results: In the LGN, staining for cytochrome oxidase and immunolabelling for synaptophysin were reduced in the parvocellular and magnocellular layers that received input from the glaucomatous eye and neurofilament protein labelling was reduced in the parvocellular layers. Cytochrome oxidase staining demonstrated the presence of denervated ocular dominance columns in layer IVC of the primary visual cortex of experimental animals. Conclusions: Pre-and post-synaptic neurochemical alterations in the magnocellular and parvocellular visual path- ways of the brain are associated with experimentally induced glaucoma in macaque monkeys.

Original languageEnglish (US)
Pages (from-to)239-243
Number of pages5
JournalAustralian and New Zealand Journal of Ophthalmology
Volume25
Issue number3
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

Fingerprint

Geniculate Bodies
Visual Pathways
Macaca
Electron Transport Complex IV
Visual Cortex
Glaucoma
Haplorhini
Neurofilament Proteins
Synaptophysin
Staining and Labeling
Eye Proteins
ocular Dominance
Trabecular Meshwork
Intraocular Pressure
Burns
Lasers
Neurons
Brain

Keywords

  • Cytochrome oxidase
  • Glaucoma
  • Lateral geniculate nucleus
  • Magnocellular
  • Neurofilaments
  • Parvocellular
  • Retina
  • Synaptophysin
  • Visua l cortex

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Magnocellular and parvocellular visual pathways are both affected in a macaque monkey model of glaucoma. / Vickers, J. C.; Hof, P. R.; Schumer, R. A.; Wang, R. F.; Podos, S. M.; Morrison, John.

In: Australian and New Zealand Journal of Ophthalmology, Vol. 25, No. 3, 01.01.1997, p. 239-243.

Research output: Contribution to journalArticle

Vickers, J. C. ; Hof, P. R. ; Schumer, R. A. ; Wang, R. F. ; Podos, S. M. ; Morrison, John. / Magnocellular and parvocellular visual pathways are both affected in a macaque monkey model of glaucoma. In: Australian and New Zealand Journal of Ophthalmology. 1997 ; Vol. 25, No. 3. pp. 239-243.
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