Abstract
Biological responses of human cells and tissues to ionizing radiation (IR) are strongly influenced by dose and dose-rate. Unlike the robust activation of cellular DNA damage responses (DDR) seen after high IR doses, the efficiency of activation of DNA damage repair and signaling pathways after much lower doses and dose-rates varies appreciably among different individuals. Genomic and functional assays measuring low dose and dose-rate IR responses repeatedly show increased inter-individual variability when cells and tissues experience DNA damage levels comparable to those experienced endogenously (due to aerobic metabolism, diet, lifestyle, etc). Complicating matters for risk assessment are recent observations of dose-response non-linearity (hyper-linearity) in the low dose range. With both physical and biological factors strongly influencing individual responses to IR at low doses and dose-rates, further radiobiological research is required to assist regulatory agencies in determining appropriate radiological protection standards for such exposures.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 296-298 |
| Number of pages | 3 |
| Journal | Health Physics |
| Volume | 110 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2016 |
| Externally published | Yes |
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Keywords
- carcinogenesis
- dose low
- genetic effects radiation
- risk estimates
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Health, Toxicology and Mutagenesis
- Epidemiology
- Medicine(all)
Cite this
Magnification of Inter-individual Variation in Biological Responses after Low Doses and Dose-Rates of Ionizing Radiation. / Wilson, Paul F.
In: Health Physics, Vol. 110, No. 3, 01.03.2016, p. 296-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Magnification of Inter-individual Variation in Biological Responses after Low Doses and Dose-Rates of Ionizing Radiation
AU - Wilson, Paul F.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Biological responses of human cells and tissues to ionizing radiation (IR) are strongly influenced by dose and dose-rate. Unlike the robust activation of cellular DNA damage responses (DDR) seen after high IR doses, the efficiency of activation of DNA damage repair and signaling pathways after much lower doses and dose-rates varies appreciably among different individuals. Genomic and functional assays measuring low dose and dose-rate IR responses repeatedly show increased inter-individual variability when cells and tissues experience DNA damage levels comparable to those experienced endogenously (due to aerobic metabolism, diet, lifestyle, etc). Complicating matters for risk assessment are recent observations of dose-response non-linearity (hyper-linearity) in the low dose range. With both physical and biological factors strongly influencing individual responses to IR at low doses and dose-rates, further radiobiological research is required to assist regulatory agencies in determining appropriate radiological protection standards for such exposures.
AB - Biological responses of human cells and tissues to ionizing radiation (IR) are strongly influenced by dose and dose-rate. Unlike the robust activation of cellular DNA damage responses (DDR) seen after high IR doses, the efficiency of activation of DNA damage repair and signaling pathways after much lower doses and dose-rates varies appreciably among different individuals. Genomic and functional assays measuring low dose and dose-rate IR responses repeatedly show increased inter-individual variability when cells and tissues experience DNA damage levels comparable to those experienced endogenously (due to aerobic metabolism, diet, lifestyle, etc). Complicating matters for risk assessment are recent observations of dose-response non-linearity (hyper-linearity) in the low dose range. With both physical and biological factors strongly influencing individual responses to IR at low doses and dose-rates, further radiobiological research is required to assist regulatory agencies in determining appropriate radiological protection standards for such exposures.
KW - carcinogenesis
KW - dose low
KW - genetic effects radiation
KW - risk estimates
UR - http://www.scopus.com/inward/record.url?scp=84957088927&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957088927&partnerID=8YFLogxK
U2 - 10.1097/HP.0000000000000453
DO - 10.1097/HP.0000000000000453
M3 - Article
C2 - 26808888
AN - SCOPUS:84957088927
VL - 110
SP - 296
EP - 298
JO - Health Physics
JF - Health Physics
SN - 0017-9078
IS - 3
ER -