Magnetic resonance thermometry at 7T for real-time monitoring and correction of ultrasound induced mild hyperthermia

Brett Z. Fite, Yu Liu, Dustin E. Kruse, Charles F. Caskey, Jeffrey H. Walton, Chun Yen Lai, Lisa M. Mahakian, Benoit Larrat, Erik Dumont, Katherine W. Ferrara

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

While Magnetic Resonance Thermometry (MRT) has been extensively utilized for non-invasive temperature measurement, there is limited data on the use of high field (≥7T) scanners for this purpose. MR-guided Focused Ultrasound (MRgFUS) is a promising non-invasive method for localized hyperthermia and drug delivery. MRT based on the temperature sensitivity of the proton resonance frequency (PRF) has been implemented in both a tissue phantom and in vivo in a mouse Met-1 tumor model, using partial parallel imaging (PPI) to speed acquisition. An MRgFUS system capable of delivering a controlled 3D acoustic dose during real time MRT with proportional, integral, and derivative (PID) feedback control was developed and validated. Real-time MRT was validated in a tofu phantom with fluoroptic temperature measurements, and acoustic heating simulations were in good agreement with MR temperature maps. In an in vivo Met-1 mouse tumor, the real-time PID feedback control is capable of maintaining the desired temperature with high accuracy. We found that real time MR control of hyperthermia is feasible at high field, and k-space based PPI techniques may be implemented for increasing temporal resolution while maintaining temperature accuracy on the order of 1°C.

Original languageEnglish (US)
Article numbere35509
JournalPLoS One
Volume7
Issue number4
DOIs
StatePublished - Apr 20 2012

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Fite, B. Z., Liu, Y., Kruse, D. E., Caskey, C. F., Walton, J. H., Lai, C. Y., Mahakian, L. M., Larrat, B., Dumont, E., & Ferrara, K. W. (2012). Magnetic resonance thermometry at 7T for real-time monitoring and correction of ultrasound induced mild hyperthermia. PLoS One, 7(4), [e35509]. https://doi.org/10.1371/journal.pone.0035509