Abstract
Magnetic resonance spectroscopy (MRS) provides unique information about the neurobiological substrates of brain function in health and disease. However, many of the physical principles underlying MRS are distinct from those underlying magnetic resonance imaging, and they may not be widely understood by neuroscientists new to this methodology. This review describes these physical principles and many of the technical methods in current use for MRS experiments. A better understanding these principles and methods may help investigators select pulse sequences and quantification methods best suited to the aims of their research program and avoid pitfalls that can hamper new investigators in this field.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 609-632 |
| Number of pages | 24 |
| Journal | Reviews in the Neurosciences |
| Volume | 26 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2015 |
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Keywords
- biophysics
- echo time
- neurochemistry
- NMR
- proton
- pulse sequences
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Magnetic resonance spectroscopy of the brain : A review of physical principles and technical methods. / Buonocore, Michael H.; Maddock, Richard J.
In: Reviews in the Neurosciences, Vol. 26, No. 6, 01.12.2015, p. 609-632.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Magnetic resonance spectroscopy of the brain
T2 - A review of physical principles and technical methods
AU - Buonocore, Michael H.
AU - Maddock, Richard J
PY - 2015/12/1
Y1 - 2015/12/1
N2 - Magnetic resonance spectroscopy (MRS) provides unique information about the neurobiological substrates of brain function in health and disease. However, many of the physical principles underlying MRS are distinct from those underlying magnetic resonance imaging, and they may not be widely understood by neuroscientists new to this methodology. This review describes these physical principles and many of the technical methods in current use for MRS experiments. A better understanding these principles and methods may help investigators select pulse sequences and quantification methods best suited to the aims of their research program and avoid pitfalls that can hamper new investigators in this field.
AB - Magnetic resonance spectroscopy (MRS) provides unique information about the neurobiological substrates of brain function in health and disease. However, many of the physical principles underlying MRS are distinct from those underlying magnetic resonance imaging, and they may not be widely understood by neuroscientists new to this methodology. This review describes these physical principles and many of the technical methods in current use for MRS experiments. A better understanding these principles and methods may help investigators select pulse sequences and quantification methods best suited to the aims of their research program and avoid pitfalls that can hamper new investigators in this field.
KW - biophysics
KW - echo time
KW - neurochemistry
KW - NMR
KW - proton
KW - pulse sequences
UR - http://www.scopus.com/inward/record.url?scp=84948740544&partnerID=8YFLogxK
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U2 - 10.1515/revneuro-2015-0010
DO - 10.1515/revneuro-2015-0010
M3 - Article
C2 - 26200810
AN - SCOPUS:84948740544
VL - 26
SP - 609
EP - 632
JO - Neural Plasticity
JF - Neural Plasticity
SN - 2090-5904
IS - 6
ER -