Magnetic resonance spectroscopy of the brain: A review of physical principles and technical methods

Michael H. Buonocore, Richard J Maddock

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Magnetic resonance spectroscopy (MRS) provides unique information about the neurobiological substrates of brain function in health and disease. However, many of the physical principles underlying MRS are distinct from those underlying magnetic resonance imaging, and they may not be widely understood by neuroscientists new to this methodology. This review describes these physical principles and many of the technical methods in current use for MRS experiments. A better understanding these principles and methods may help investigators select pulse sequences and quantification methods best suited to the aims of their research program and avoid pitfalls that can hamper new investigators in this field.

Original languageEnglish (US)
Pages (from-to)609-632
Number of pages24
JournalReviews in the Neurosciences
Volume26
Issue number6
DOIs
StatePublished - Dec 1 2015

Keywords

  • biophysics
  • echo time
  • neurochemistry
  • NMR
  • proton
  • pulse sequences

ASJC Scopus subject areas

  • Neuroscience(all)

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