Magnetic resonance imaging and water-suppressed proton magnetic resonance spectroscopic imaging were used to study. N-acetylaspartate and other metabolites in a patient with severe hypoxic-ischemic encephalopathy. The N- acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline-containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water-suppressed proton magnetic resonance spectroscopic imaging measurements of N-acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.
|Original language||English (US)|
|Number of pages||5|
|Journal||Annals of Neurology|
|State||Published - Apr 1994|
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