Abstract
Magnetic resonance imaging and water-suppressed proton magnetic resonance spectroscopic imaging were used to study. N-acetylaspartate and other metabolites in a patient with severe hypoxic-ischemic encephalopathy. The N- acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline-containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water-suppressed proton magnetic resonance spectroscopic imaging measurements of N-acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.
Original language | English (US) |
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Pages (from-to) | 490-494 |
Number of pages | 5 |
Journal | Annals of Neurology |
Volume | 35 |
Issue number | 4 |
State | Published - Apr 1994 |
Externally published | Yes |
ASJC Scopus subject areas
- Neuroscience(all)