Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy

S. H. Graham, D. J. Meyerhoff, L. Bayne, Frank R Sharp, M. W. Weiner

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Magnetic resonance imaging and water-suppressed proton magnetic resonance spectroscopic imaging were used to study. N-acetylaspartate and other metabolites in a patient with severe hypoxic-ischemic encephalopathy. The N- acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline-containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water-suppressed proton magnetic resonance spectroscopic imaging measurements of N-acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.

Original languageEnglish (US)
Pages (from-to)490-494
Number of pages5
JournalAnnals of Neurology
Volume35
Issue number4
StatePublished - Apr 1994
Externally publishedYes

Fingerprint

Brain Hypoxia-Ischemia
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Protons
Water
Prosencephalon
Choline
Astrocytes
Neurons
Brain
N-acetylaspartate

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Graham, S. H., Meyerhoff, D. J., Bayne, L., Sharp, F. R., & Weiner, M. W. (1994). Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy. Annals of Neurology, 35(4), 490-494.

Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy. / Graham, S. H.; Meyerhoff, D. J.; Bayne, L.; Sharp, Frank R; Weiner, M. W.

In: Annals of Neurology, Vol. 35, No. 4, 04.1994, p. 490-494.

Research output: Contribution to journalArticle

Graham, SH, Meyerhoff, DJ, Bayne, L, Sharp, FR & Weiner, MW 1994, 'Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy', Annals of Neurology, vol. 35, no. 4, pp. 490-494.
Graham, S. H. ; Meyerhoff, D. J. ; Bayne, L. ; Sharp, Frank R ; Weiner, M. W. / Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy. In: Annals of Neurology. 1994 ; Vol. 35, No. 4. pp. 490-494.
@article{968c4b6a9d7741e4bfba8ac3112978fa,
title = "Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy",
abstract = "Magnetic resonance imaging and water-suppressed proton magnetic resonance spectroscopic imaging were used to study. N-acetylaspartate and other metabolites in a patient with severe hypoxic-ischemic encephalopathy. The N- acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline-containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water-suppressed proton magnetic resonance spectroscopic imaging measurements of N-acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.",
author = "Graham, {S. H.} and Meyerhoff, {D. J.} and L. Bayne and Sharp, {Frank R} and Weiner, {M. W.}",
year = "1994",
month = "4",
language = "English (US)",
volume = "35",
pages = "490--494",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy

AU - Graham, S. H.

AU - Meyerhoff, D. J.

AU - Bayne, L.

AU - Sharp, Frank R

AU - Weiner, M. W.

PY - 1994/4

Y1 - 1994/4

N2 - Magnetic resonance imaging and water-suppressed proton magnetic resonance spectroscopic imaging were used to study. N-acetylaspartate and other metabolites in a patient with severe hypoxic-ischemic encephalopathy. The N- acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline-containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water-suppressed proton magnetic resonance spectroscopic imaging measurements of N-acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.

AB - Magnetic resonance imaging and water-suppressed proton magnetic resonance spectroscopic imaging were used to study. N-acetylaspartate and other metabolites in a patient with severe hypoxic-ischemic encephalopathy. The N- acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline-containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water-suppressed proton magnetic resonance spectroscopic imaging measurements of N-acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.

UR - http://www.scopus.com/inward/record.url?scp=0028329158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028329158&partnerID=8YFLogxK

M3 - Article

C2 - 8154879

AN - SCOPUS:0028329158

VL - 35

SP - 490

EP - 494

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 4

ER -