Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy

S. H. Graham, D. J. Meyerhoff, L. Bayne, Frank R Sharp, M. W. Weiner

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Abstract

Magnetic resonance imaging and water-suppressed proton magnetic resonance spectroscopic imaging were used to study. N-acetylaspartate and other metabolites in a patient with severe hypoxic-ischemic encephalopathy. The N- acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline-containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water-suppressed proton magnetic resonance spectroscopic imaging measurements of N-acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.

Original languageEnglish (US)
Pages (from-to)490-494
Number of pages5
JournalAnnals of Neurology
Volume35
Issue number4
StatePublished - Apr 1994
Externally publishedYes

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Graham, S. H., Meyerhoff, D. J., Bayne, L., Sharp, F. R., & Weiner, M. W. (1994). Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy. Annals of Neurology, 35(4), 490-494.