Abstract
Magnetic resonance imaging and water-suppressed proton magnetic resonance spectroscopic imaging were used to study. N-acetylaspartate and other metabolites in a patient with severe hypoxic-ischemic encephalopathy. The N- acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline-containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water-suppressed proton magnetic resonance spectroscopic imaging measurements of N-acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 490-494 |
| Number of pages | 5 |
| Journal | Annals of Neurology |
| Volume | 35 |
| Issue number | 4 |
| State | Published - Apr 1994 |
| Externally published | Yes |
ASJC Scopus subject areas
- Neuroscience(all)
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Graham, S. H., Meyerhoff, D. J., Bayne, L., Sharp, F. R., & Weiner, M. W. (1994). Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy. Annals of Neurology, 35(4), 490-494.