Abstract
Magnetic resonance imaging and water-suppressed proton magnetic resonance spectroscopic imaging were used to study. N-acetylaspartate and other metabolites in a patient with severe hypoxic-ischemic encephalopathy. The N- acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline-containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water-suppressed proton magnetic resonance spectroscopic imaging measurements of N-acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 490-494 |
| Number of pages | 5 |
| Journal | Annals of Neurology |
| Volume | 35 |
| Issue number | 4 |
| State | Published - Apr 1994 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy. / Graham, S. H.; Meyerhoff, D. J.; Bayne, L.; Sharp, Frank R; Weiner, M. W.
In: Annals of Neurology, Vol. 35, No. 4, 04.1994, p. 490-494.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Magnetic resonance spectroscopy of N-acetylaspartate in hypoxic-ischemic encephalopathy
AU - Graham, S. H.
AU - Meyerhoff, D. J.
AU - Bayne, L.
AU - Sharp, Frank R
AU - Weiner, M. W.
PY - 1994/4
Y1 - 1994/4
N2 - Magnetic resonance imaging and water-suppressed proton magnetic resonance spectroscopic imaging were used to study. N-acetylaspartate and other metabolites in a patient with severe hypoxic-ischemic encephalopathy. The N- acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline-containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water-suppressed proton magnetic resonance spectroscopic imaging measurements of N-acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.
AB - Magnetic resonance imaging and water-suppressed proton magnetic resonance spectroscopic imaging were used to study. N-acetylaspartate and other metabolites in a patient with severe hypoxic-ischemic encephalopathy. The N- acetylaspartate signal, a putative marker of neuronal density, was markedly reduced in the forebrain. The relative signal intensity of choline-containing metabolites, which are more abundant in astrocytes than neurons, was increased. These results support the hypothesis that water-suppressed proton magnetic resonance spectroscopic imaging measurements of N-acetylaspartate may be useful for noninvasive detection of selective neuronal loss in a variety of disease states in the human brain.
UR - http://www.scopus.com/inward/record.url?scp=0028329158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028329158&partnerID=8YFLogxK
M3 - Article
C2 - 8154879
AN - SCOPUS:0028329158
VL - 35
SP - 490
EP - 494
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 4
ER -