Abstract
Magnetic resonance spectroscopy (MRS) is a valuable tool for the study of myocardial ischemia. Phosphorus (31P) MRS can detect changes in high-energy phosphates resulting from ischemia and has been used to determine the sensitivity of metabolic changes to ischemia as well as to investigate the metabolic factors important for myocardial dysfunction. The mechanisms mediating postischemic dysfunction have been investigated using 31P MRS, as have interventions to limit metabolic and functional damage from ischemia. These investigations have laid the groundwork for human cardiac studies. While abnormalities following myocardial infarction have been shown in man, further work must be performed to reliably acquire localized spectra under conditions of ischemia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 969-972 |
| Number of pages | 4 |
| Journal | Investigative Radiology |
| Volume | 24 |
| Issue number | 12 |
| State | Published - 1989 |
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Keywords
- coronary artery disease
- high-energy phosphates
- myocardial ischemia
- nuclear magnetic resonance
- phosphorous-31 spectroscopy
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Magnetic resonance spectroscopy. Evaluation of ischemic heart disease. / Schaefer, Saul; Schwartz, G. G.; Gober, J. R.; Massie, B.; Weiner, M. W.
In: Investigative Radiology, Vol. 24, No. 12, 1989, p. 969-972.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Magnetic resonance spectroscopy. Evaluation of ischemic heart disease
AU - Schaefer, Saul
AU - Schwartz, G. G.
AU - Gober, J. R.
AU - Massie, B.
AU - Weiner, M. W.
PY - 1989
Y1 - 1989
N2 - Magnetic resonance spectroscopy (MRS) is a valuable tool for the study of myocardial ischemia. Phosphorus (31P) MRS can detect changes in high-energy phosphates resulting from ischemia and has been used to determine the sensitivity of metabolic changes to ischemia as well as to investigate the metabolic factors important for myocardial dysfunction. The mechanisms mediating postischemic dysfunction have been investigated using 31P MRS, as have interventions to limit metabolic and functional damage from ischemia. These investigations have laid the groundwork for human cardiac studies. While abnormalities following myocardial infarction have been shown in man, further work must be performed to reliably acquire localized spectra under conditions of ischemia.
AB - Magnetic resonance spectroscopy (MRS) is a valuable tool for the study of myocardial ischemia. Phosphorus (31P) MRS can detect changes in high-energy phosphates resulting from ischemia and has been used to determine the sensitivity of metabolic changes to ischemia as well as to investigate the metabolic factors important for myocardial dysfunction. The mechanisms mediating postischemic dysfunction have been investigated using 31P MRS, as have interventions to limit metabolic and functional damage from ischemia. These investigations have laid the groundwork for human cardiac studies. While abnormalities following myocardial infarction have been shown in man, further work must be performed to reliably acquire localized spectra under conditions of ischemia.
KW - coronary artery disease
KW - high-energy phosphates
KW - myocardial ischemia
KW - nuclear magnetic resonance
KW - phosphorous-31 spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=0024833894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024833894&partnerID=8YFLogxK
M3 - Article
C2 - 2691443
AN - SCOPUS:0024833894
VL - 24
SP - 969
EP - 972
JO - Investigative Radiology
JF - Investigative Radiology
SN - 0020-9996
IS - 12
ER -