Magnetic resonance spectroscopy. Evaluation of ischemic heart disease

Saul Schaefer, G. G. Schwartz, J. R. Gober, B. Massie, M. W. Weiner

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Magnetic resonance spectroscopy (MRS) is a valuable tool for the study of myocardial ischemia. Phosphorus (31P) MRS can detect changes in high-energy phosphates resulting from ischemia and has been used to determine the sensitivity of metabolic changes to ischemia as well as to investigate the metabolic factors important for myocardial dysfunction. The mechanisms mediating postischemic dysfunction have been investigated using 31P MRS, as have interventions to limit metabolic and functional damage from ischemia. These investigations have laid the groundwork for human cardiac studies. While abnormalities following myocardial infarction have been shown in man, further work must be performed to reliably acquire localized spectra under conditions of ischemia.

Original languageEnglish (US)
Pages (from-to)969-972
Number of pages4
JournalInvestigative Radiology
Volume24
Issue number12
StatePublished - 1989

Keywords

  • coronary artery disease
  • high-energy phosphates
  • myocardial ischemia
  • nuclear magnetic resonance
  • phosphorous-31 spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

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    Schaefer, S., Schwartz, G. G., Gober, J. R., Massie, B., & Weiner, M. W. (1989). Magnetic resonance spectroscopy. Evaluation of ischemic heart disease. Investigative Radiology, 24(12), 969-972.