Magnetic resonance spectroscopy. Evaluation of ischemic heart disease

Saul Schaefer; G. G. Schwartz; J. R. Gober; B. Massie; M. W. Weiner

Magnetic resonance spectroscopy. Evaluation of ischemic heart disease

Saul Schaefer, G. G. Schwartz, J. R. Gober, B. Massie, M. W. Weiner

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Magnetic resonance spectroscopy (MRS) is a valuable tool for the study of myocardial ischemia. Phosphorus (³¹P) MRS can detect changes in high-energy phosphates resulting from ischemia and has been used to determine the sensitivity of metabolic changes to ischemia as well as to investigate the metabolic factors important for myocardial dysfunction. The mechanisms mediating postischemic dysfunction have been investigated using ³¹P MRS, as have interventions to limit metabolic and functional damage from ischemia. These investigations have laid the groundwork for human cardiac studies. While abnormalities following myocardial infarction have been shown in man, further work must be performed to reliably acquire localized spectra under conditions of ischemia.

Original language	English (US)
Pages (from-to)	969-972
Number of pages	4
Journal	Investigative Radiology
Volume	24
Issue number	12
State	Published - 1989

Keywords

coronary artery disease
high-energy phosphates
myocardial ischemia
nuclear magnetic resonance
phosphorous-31 spectroscopy

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Radiological and Ultrasound Technology

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title = "Magnetic resonance spectroscopy. Evaluation of ischemic heart disease",

abstract = "Magnetic resonance spectroscopy (MRS) is a valuable tool for the study of myocardial ischemia. Phosphorus (31P) MRS can detect changes in high-energy phosphates resulting from ischemia and has been used to determine the sensitivity of metabolic changes to ischemia as well as to investigate the metabolic factors important for myocardial dysfunction. The mechanisms mediating postischemic dysfunction have been investigated using 31P MRS, as have interventions to limit metabolic and functional damage from ischemia. These investigations have laid the groundwork for human cardiac studies. While abnormalities following myocardial infarction have been shown in man, further work must be performed to reliably acquire localized spectra under conditions of ischemia.",

keywords = "coronary artery disease, high-energy phosphates, myocardial ischemia, nuclear magnetic resonance, phosphorous-31 spectroscopy",

author = "Saul Schaefer and Schwartz, {G. G.} and Gober, {J. R.} and B. Massie and Weiner, {M. W.}",

year = "1989",

language = "English (US)",

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journal = "Investigative Radiology",

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T1 - Magnetic resonance spectroscopy. Evaluation of ischemic heart disease

AU - Schaefer, Saul

AU - Schwartz, G. G.

AU - Gober, J. R.

AU - Massie, B.

AU - Weiner, M. W.

PY - 1989

Y1 - 1989

N2 - Magnetic resonance spectroscopy (MRS) is a valuable tool for the study of myocardial ischemia. Phosphorus (31P) MRS can detect changes in high-energy phosphates resulting from ischemia and has been used to determine the sensitivity of metabolic changes to ischemia as well as to investigate the metabolic factors important for myocardial dysfunction. The mechanisms mediating postischemic dysfunction have been investigated using 31P MRS, as have interventions to limit metabolic and functional damage from ischemia. These investigations have laid the groundwork for human cardiac studies. While abnormalities following myocardial infarction have been shown in man, further work must be performed to reliably acquire localized spectra under conditions of ischemia.

AB - Magnetic resonance spectroscopy (MRS) is a valuable tool for the study of myocardial ischemia. Phosphorus (31P) MRS can detect changes in high-energy phosphates resulting from ischemia and has been used to determine the sensitivity of metabolic changes to ischemia as well as to investigate the metabolic factors important for myocardial dysfunction. The mechanisms mediating postischemic dysfunction have been investigated using 31P MRS, as have interventions to limit metabolic and functional damage from ischemia. These investigations have laid the groundwork for human cardiac studies. While abnormalities following myocardial infarction have been shown in man, further work must be performed to reliably acquire localized spectra under conditions of ischemia.

KW - coronary artery disease

KW - high-energy phosphates

KW - myocardial ischemia

KW - nuclear magnetic resonance

KW - phosphorous-31 spectroscopy

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AN - SCOPUS:0024833894

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JO - Investigative Radiology

JF - Investigative Radiology

SN - 0020-9996

IS - 12

ER -

Magnetic resonance spectroscopy. Evaluation of ischemic heart disease

Abstract

Keywords

ASJC Scopus subject areas

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