Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease – data from the Osteoarthritis Initiative

Barton L Wise, J. Niu, A. Guermazi, F. Liu, U. Heilmeier, E. Ku, J. A. Lynch, Y. Zhang, D. T. Felson, C. K. Kwoh, Nancy E Lane

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective Isolated lateral compartment tibiofemoral radiographic osteoarthritis (IL-ROA) is an understudied form of knee osteoarthritis (OA). The objective of the present study was to characterize Magnetic Resonance Imaging (MRI) abnormalities and MR-T2 relaxation time measurements associated with IL-ROA and with isolated medial compartment ROA (IM-ROA) compared with knees without OA. Method 200 case subjects with IL-ROA (Kellgren/Lawrence (K/L) grade ≥ 2 and joint space narrowing (JSN) > 0 in the lateral compartment but JSN = 0 in the medial compartment) were randomly selected from the Osteoarthritis Initiative baseline visit. 200 cases with IM-ROA and 200 controls were frequency matched to the IL-ROA cases. Cases and controls were analyzed for odds of having a subregion with >10% cartilage area affected, with ≥25% bone marrow lesions (BML), with meniscal tear or maceration, and for association with cartilage T2 values. Results IL-ROA was more strongly associated with ipsilateral MRI knee pathologies than IM-ROA (IL-ROA: OR = 135.2 for size of cartilage lesion, 95% CI 42.7–427.4; OR = 145.4 for large size BML, 95% CI 41.5–509.5; OR = 176 for meniscal tears, 95% CI 59.8–517.7; IM-ROA: OR = 28.4 for size of cartilage lesion, 95% CI 14.7–54.7; OR = 38.1 for size of BML, 95% CI 12.7–114; OR = 37.0 for meniscal tears, 95% CI 12–113.6). Cartilage T2 values were higher in both tibial and medial femoral compartments in IL-ROA, but in IM-ROA were only significantly different from controls in the medial femur. Conclusion IL-ROA knees show a greater prevalence and severity of MRI lesions and higher cartilage T2 values than IM-ROA knees compared with controls.

Original languageEnglish (US)
Pages (from-to)85-93
Number of pages9
JournalOsteoarthritis and Cartilage
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Knee Osteoarthritis
Cartilage
Time measurement
Osteoarthritis
Magnetic resonance imaging
Relaxation time
Magnetic Resonance Imaging
Bone
Tears
Bone Marrow
Knee
Joints
Pathology
Thigh
Femur

Keywords

  • Cartilage
  • Knee osteoarthritis
  • Lateral compartment
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine
  • Biomedical Engineering

Cite this

@article{929c19ea59f0467c89d59a93c375c6c7,
title = "Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease – data from the Osteoarthritis Initiative",
abstract = "Objective Isolated lateral compartment tibiofemoral radiographic osteoarthritis (IL-ROA) is an understudied form of knee osteoarthritis (OA). The objective of the present study was to characterize Magnetic Resonance Imaging (MRI) abnormalities and MR-T2 relaxation time measurements associated with IL-ROA and with isolated medial compartment ROA (IM-ROA) compared with knees without OA. Method 200 case subjects with IL-ROA (Kellgren/Lawrence (K/L) grade ≥ 2 and joint space narrowing (JSN) > 0 in the lateral compartment but JSN = 0 in the medial compartment) were randomly selected from the Osteoarthritis Initiative baseline visit. 200 cases with IM-ROA and 200 controls were frequency matched to the IL-ROA cases. Cases and controls were analyzed for odds of having a subregion with >10{\%} cartilage area affected, with ≥25{\%} bone marrow lesions (BML), with meniscal tear or maceration, and for association with cartilage T2 values. Results IL-ROA was more strongly associated with ipsilateral MRI knee pathologies than IM-ROA (IL-ROA: OR = 135.2 for size of cartilage lesion, 95{\%} CI 42.7–427.4; OR = 145.4 for large size BML, 95{\%} CI 41.5–509.5; OR = 176 for meniscal tears, 95{\%} CI 59.8–517.7; IM-ROA: OR = 28.4 for size of cartilage lesion, 95{\%} CI 14.7–54.7; OR = 38.1 for size of BML, 95{\%} CI 12.7–114; OR = 37.0 for meniscal tears, 95{\%} CI 12–113.6). Cartilage T2 values were higher in both tibial and medial femoral compartments in IL-ROA, but in IM-ROA were only significantly different from controls in the medial femur. Conclusion IL-ROA knees show a greater prevalence and severity of MRI lesions and higher cartilage T2 values than IM-ROA knees compared with controls.",
keywords = "Cartilage, Knee osteoarthritis, Lateral compartment, Magnetic resonance imaging",
author = "Wise, {Barton L} and J. Niu and A. Guermazi and F. Liu and U. Heilmeier and E. Ku and Lynch, {J. A.} and Y. Zhang and Felson, {D. T.} and Kwoh, {C. K.} and Lane, {Nancy E}",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.joca.2016.08.002",
language = "English (US)",
volume = "25",
pages = "85--93",
journal = "Osteoarthritis and Cartilage",
issn = "1063-4584",
publisher = "W.B. Saunders Ltd",
number = "1",

}

TY - JOUR

T1 - Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic knee osteoarthritis than in isolated medial compartment disease – data from the Osteoarthritis Initiative

AU - Wise, Barton L

AU - Niu, J.

AU - Guermazi, A.

AU - Liu, F.

AU - Heilmeier, U.

AU - Ku, E.

AU - Lynch, J. A.

AU - Zhang, Y.

AU - Felson, D. T.

AU - Kwoh, C. K.

AU - Lane, Nancy E

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Objective Isolated lateral compartment tibiofemoral radiographic osteoarthritis (IL-ROA) is an understudied form of knee osteoarthritis (OA). The objective of the present study was to characterize Magnetic Resonance Imaging (MRI) abnormalities and MR-T2 relaxation time measurements associated with IL-ROA and with isolated medial compartment ROA (IM-ROA) compared with knees without OA. Method 200 case subjects with IL-ROA (Kellgren/Lawrence (K/L) grade ≥ 2 and joint space narrowing (JSN) > 0 in the lateral compartment but JSN = 0 in the medial compartment) were randomly selected from the Osteoarthritis Initiative baseline visit. 200 cases with IM-ROA and 200 controls were frequency matched to the IL-ROA cases. Cases and controls were analyzed for odds of having a subregion with >10% cartilage area affected, with ≥25% bone marrow lesions (BML), with meniscal tear or maceration, and for association with cartilage T2 values. Results IL-ROA was more strongly associated with ipsilateral MRI knee pathologies than IM-ROA (IL-ROA: OR = 135.2 for size of cartilage lesion, 95% CI 42.7–427.4; OR = 145.4 for large size BML, 95% CI 41.5–509.5; OR = 176 for meniscal tears, 95% CI 59.8–517.7; IM-ROA: OR = 28.4 for size of cartilage lesion, 95% CI 14.7–54.7; OR = 38.1 for size of BML, 95% CI 12.7–114; OR = 37.0 for meniscal tears, 95% CI 12–113.6). Cartilage T2 values were higher in both tibial and medial femoral compartments in IL-ROA, but in IM-ROA were only significantly different from controls in the medial femur. Conclusion IL-ROA knees show a greater prevalence and severity of MRI lesions and higher cartilage T2 values than IM-ROA knees compared with controls.

AB - Objective Isolated lateral compartment tibiofemoral radiographic osteoarthritis (IL-ROA) is an understudied form of knee osteoarthritis (OA). The objective of the present study was to characterize Magnetic Resonance Imaging (MRI) abnormalities and MR-T2 relaxation time measurements associated with IL-ROA and with isolated medial compartment ROA (IM-ROA) compared with knees without OA. Method 200 case subjects with IL-ROA (Kellgren/Lawrence (K/L) grade ≥ 2 and joint space narrowing (JSN) > 0 in the lateral compartment but JSN = 0 in the medial compartment) were randomly selected from the Osteoarthritis Initiative baseline visit. 200 cases with IM-ROA and 200 controls were frequency matched to the IL-ROA cases. Cases and controls were analyzed for odds of having a subregion with >10% cartilage area affected, with ≥25% bone marrow lesions (BML), with meniscal tear or maceration, and for association with cartilage T2 values. Results IL-ROA was more strongly associated with ipsilateral MRI knee pathologies than IM-ROA (IL-ROA: OR = 135.2 for size of cartilage lesion, 95% CI 42.7–427.4; OR = 145.4 for large size BML, 95% CI 41.5–509.5; OR = 176 for meniscal tears, 95% CI 59.8–517.7; IM-ROA: OR = 28.4 for size of cartilage lesion, 95% CI 14.7–54.7; OR = 38.1 for size of BML, 95% CI 12.7–114; OR = 37.0 for meniscal tears, 95% CI 12–113.6). Cartilage T2 values were higher in both tibial and medial femoral compartments in IL-ROA, but in IM-ROA were only significantly different from controls in the medial femur. Conclusion IL-ROA knees show a greater prevalence and severity of MRI lesions and higher cartilage T2 values than IM-ROA knees compared with controls.

KW - Cartilage

KW - Knee osteoarthritis

KW - Lateral compartment

KW - Magnetic resonance imaging

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VL - 25

SP - 85

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JO - Osteoarthritis and Cartilage

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