Magnetic nanoparticle-supported lipid bilayers for drug delivery

Stephanie J. Mattingly, Martin G. Otoole, Kurtis T. James, Geoffrey J. Clark, Michael H. Nantz

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Magnetic nanoparticle-supported lipid bilayers (SLBs) constructed around core-shell Fe3O4-SiO2 nanoparticles (SNPs) were prepared and evaluated as potential drug carriers. We describe how an oxime ether lipid can be mixed with SNPs to produce lipid-particle assemblies with highly positive ζ potential. To demonstrate the potential of the resultant cationic SLBs, the particles were loaded with either the anticancer drug doxorubicin or an amphiphilic analogue, prepared to facilitate integration into the supported lipid bilayer, and then examined in studies against MCF-7 breast cancer cells. The assemblies were rapidly internalized and exhibited higher toxicity than treatments with doxorubicin alone. The magnetic SLBs were also shown to increase the efficacy of unmodified doxorubicin.

Original languageEnglish (US)
Pages (from-to)3326-3332
Number of pages7
JournalLangmuir
Volume31
Issue number11
DOIs
StatePublished - Mar 24 2015
Externally publishedYes

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

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  • Cite this

    Mattingly, S. J., Otoole, M. G., James, K. T., Clark, G. J., & Nantz, M. H. (2015). Magnetic nanoparticle-supported lipid bilayers for drug delivery. Langmuir, 31(11), 3326-3332. https://doi.org/10.1021/la504830z