Magnetic nanoparticle-supported lipid bilayers for drug delivery

Stephanie J. Mattingly, Martin G. Otoole, Kurtis T. James, Geoffrey J. Clark, Michael H. Nantz

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Magnetic nanoparticle-supported lipid bilayers (SLBs) constructed around core-shell Fe3O4-SiO2 nanoparticles (SNPs) were prepared and evaluated as potential drug carriers. We describe how an oxime ether lipid can be mixed with SNPs to produce lipid-particle assemblies with highly positive ζ potential. To demonstrate the potential of the resultant cationic SLBs, the particles were loaded with either the anticancer drug doxorubicin or an amphiphilic analogue, prepared to facilitate integration into the supported lipid bilayer, and then examined in studies against MCF-7 breast cancer cells. The assemblies were rapidly internalized and exhibited higher toxicity than treatments with doxorubicin alone. The magnetic SLBs were also shown to increase the efficacy of unmodified doxorubicin.

Original languageEnglish (US)
Pages (from-to)3326-3332
Number of pages7
JournalLangmuir
Volume31
Issue number11
DOIs
StatePublished - Mar 24 2015
Externally publishedYes

Fingerprint

Lipid bilayers
Drug delivery
lipids
delivery
drugs
Doxorubicin
Nanoparticles
nanoparticles
Lipids
assemblies
Drug Carriers
Oximes
Ether
Toxicity
Ethers
Cells
breast
toxicity
ethers
cancer

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Mattingly, S. J., Otoole, M. G., James, K. T., Clark, G. J., & Nantz, M. H. (2015). Magnetic nanoparticle-supported lipid bilayers for drug delivery. Langmuir, 31(11), 3326-3332. https://doi.org/10.1021/la504830z

Magnetic nanoparticle-supported lipid bilayers for drug delivery. / Mattingly, Stephanie J.; Otoole, Martin G.; James, Kurtis T.; Clark, Geoffrey J.; Nantz, Michael H.

In: Langmuir, Vol. 31, No. 11, 24.03.2015, p. 3326-3332.

Research output: Contribution to journalArticle

Mattingly, SJ, Otoole, MG, James, KT, Clark, GJ & Nantz, MH 2015, 'Magnetic nanoparticle-supported lipid bilayers for drug delivery', Langmuir, vol. 31, no. 11, pp. 3326-3332. https://doi.org/10.1021/la504830z
Mattingly SJ, Otoole MG, James KT, Clark GJ, Nantz MH. Magnetic nanoparticle-supported lipid bilayers for drug delivery. Langmuir. 2015 Mar 24;31(11):3326-3332. https://doi.org/10.1021/la504830z
Mattingly, Stephanie J. ; Otoole, Martin G. ; James, Kurtis T. ; Clark, Geoffrey J. ; Nantz, Michael H. / Magnetic nanoparticle-supported lipid bilayers for drug delivery. In: Langmuir. 2015 ; Vol. 31, No. 11. pp. 3326-3332.
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