Magnetic nanoparticle probes

Leslie Laconte, Nitin Nitin, Gang Bao

Research output: Contribution to journalArticlepeer-review

183 Scopus citations


The various methods for synthesis and functionalization of the magnetic nanoparticle probes for their potential clinical usage and design approaches are highlighted. Magnetic nanoparticles are more efficient than micrometer-sized magnetic particles as relaxation promoters. High-performance magnetic nanoparticle probes for deep-tissue molecular imaging is being developed for deep-tissue molecular imaging using MRI by integrating in vivo delivery, targeting/sensing, and signal transduction functions. The probes consist of a small coated magnetic nanoparticle conjugated with a stem-loop hairpin oligonucleotide probe complementary to the target mRNA. The superparamagnetic iron oxide (SPIO) probes promise increased sensitivity in disease detection in vivo.

Original languageEnglish (US)
Pages (from-to)32-38
Number of pages7
JournalMaterials Today
Issue number5 SUPPL. 1
StatePublished - May 2005
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)


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