The various methods for synthesis and functionalization of the magnetic nanoparticle probes for their potential clinical usage and design approaches are highlighted. Magnetic nanoparticles are more efficient than micrometer-sized magnetic particles as relaxation promoters. High-performance magnetic nanoparticle probes for deep-tissue molecular imaging is being developed for deep-tissue molecular imaging using MRI by integrating in vivo delivery, targeting/sensing, and signal transduction functions. The probes consist of a small coated magnetic nanoparticle conjugated with a stem-loop hairpin oligonucleotide probe complementary to the target mRNA. The superparamagnetic iron oxide (SPIO) probes promise increased sensitivity in disease detection in vivo.
ASJC Scopus subject areas
- Materials Science(all)