Magnetic field-induced cyclizations of amino-esters and -carbonates bound to iron oxide nanoparticles

R. J. Knipp, O. Uradu, M. H. Nantz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A panel of amino-esters and amino-carbonates was prepared and evaluated for their ability to undergo thermally-induced intramolecular cyclization to form the corresponding lactams and oxazolidinones. We found that gew-dimethylated carbonate 16, the precursor to a 7-membered oxazolidinone, had ideal properties for use as a linker between drug and NP. To generate the heat necessary for intramolecular cyclization, we have devised a method to covalently load the amino-linkers onto Fe3O4 nanoparticles.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Pages251-254
Number of pages4
Volume3
StatePublished - 2013
Externally publishedYes
EventNanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 - Washington, DC, United States
Duration: May 12 2013May 16 2013

Other

OtherNanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
CountryUnited States
CityWashington, DC
Period5/12/135/16/13

Keywords

  • AMF
  • Controlled release
  • Intramolecular cyclization
  • Iron oxide
  • Nanoparticles

ASJC Scopus subject areas

  • Biotechnology

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  • Cite this

    Knipp, R. J., Uradu, O., & Nantz, M. H. (2013). Magnetic field-induced cyclizations of amino-esters and -carbonates bound to iron oxide nanoparticles. In Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 (Vol. 3, pp. 251-254)