Abstract
A panel of amino-esters and amino-carbonates was prepared and evaluated for their ability to undergo thermally-induced intramolecular cyclization to form the corresponding lactams and oxazolidinones. We found that gew-dimethylated carbonate 16, the precursor to a 7-membered oxazolidinone, had ideal properties for use as a linker between drug and NP. To generate the heat necessary for intramolecular cyclization, we have devised a method to covalently load the amino-linkers onto Fe3O4 nanoparticles.
| Original language | English (US) |
|---|---|
| Title of host publication | Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 |
| Pages | 251-254 |
| Number of pages | 4 |
| Volume | 3 |
| State | Published - 2013 |
| Externally published | Yes |
| Event | Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 - Washington, DC, United States Duration: May 12 2013 → May 16 2013 |
Other
| Other | Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 |
|---|---|
| Country | United States |
| City | Washington, DC |
| Period | 5/12/13 → 5/16/13 |
Keywords
- AMF
- Controlled release
- Intramolecular cyclization
- Iron oxide
- Nanoparticles
ASJC Scopus subject areas
- Biotechnology
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Cite this
Knipp, R. J., Uradu, O., & Nantz, M. H. (2013). Magnetic field-induced cyclizations of amino-esters and -carbonates bound to iron oxide nanoparticles. In Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 (Vol. 3, pp. 251-254)