Magnetic field-induced cyclizations of amino-esters and -carbonates bound to iron oxide nanoparticles

R. J. Knipp; O. Uradu; M. H. Nantz

Magnetic field-induced cyclizations of amino-esters and -carbonates bound to iron oxide nanoparticles

R. J. Knipp, O. Uradu, M. H. Nantz

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

A panel of amino-esters and amino-carbonates was prepared and evaluated for their ability to undergo thermally-induced intramolecular cyclization to form the corresponding lactams and oxazolidinones. We found that gew-dimethylated carbonate 16, the precursor to a 7-membered oxazolidinone, had ideal properties for use as a linker between drug and NP. To generate the heat necessary for intramolecular cyclization, we have devised a method to covalently load the amino-linkers onto Fe₃O₄ nanoparticles.

Original language	English (US)
Title of host publication	Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Pages	251-254
Number of pages	4
Volume	3
State	Published - 2013
Externally published	Yes
Event	Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 - Washington, DC, United States Duration: May 12 2013 → May 16 2013

Other

Other	Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013
Country	United States
City	Washington, DC
Period	5/12/13 → 5/16/13

Keywords

AMF
Controlled release
Intramolecular cyclization
Iron oxide
Nanoparticles

ASJC Scopus subject areas

Biotechnology

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Knipp, RJ, Uradu, O & Nantz, MH 2013, Magnetic field-induced cyclizations of amino-esters and -carbonates bound to iron oxide nanoparticles. in Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013. vol. 3, pp. 251-254, Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013, Washington, DC, United States, 5/12/13.

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title = "Magnetic field-induced cyclizations of amino-esters and -carbonates bound to iron oxide nanoparticles",

abstract = "A panel of amino-esters and amino-carbonates was prepared and evaluated for their ability to undergo thermally-induced intramolecular cyclization to form the corresponding lactams and oxazolidinones. We found that gew-dimethylated carbonate 16, the precursor to a 7-membered oxazolidinone, had ideal properties for use as a linker between drug and NP. To generate the heat necessary for intramolecular cyclization, we have devised a method to covalently load the amino-linkers onto Fe3O4 nanoparticles.",

keywords = "AMF, Controlled release, Intramolecular cyclization, Iron oxide, Nanoparticles",

author = "Knipp, {R. J.} and O. Uradu and Nantz, {M. H.}",

year = "2013",

language = "English (US)",

isbn = "9781482205862",

volume = "3",

pages = "251--254",

booktitle = "Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013",

note = "Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013 ; Conference date: 12-05-2013 Through 16-05-2013",

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TY - GEN

T1 - Magnetic field-induced cyclizations of amino-esters and -carbonates bound to iron oxide nanoparticles

AU - Knipp, R. J.

AU - Uradu, O.

AU - Nantz, M. H.

PY - 2013

Y1 - 2013

N2 - A panel of amino-esters and amino-carbonates was prepared and evaluated for their ability to undergo thermally-induced intramolecular cyclization to form the corresponding lactams and oxazolidinones. We found that gew-dimethylated carbonate 16, the precursor to a 7-membered oxazolidinone, had ideal properties for use as a linker between drug and NP. To generate the heat necessary for intramolecular cyclization, we have devised a method to covalently load the amino-linkers onto Fe3O4 nanoparticles.

AB - A panel of amino-esters and amino-carbonates was prepared and evaluated for their ability to undergo thermally-induced intramolecular cyclization to form the corresponding lactams and oxazolidinones. We found that gew-dimethylated carbonate 16, the precursor to a 7-membered oxazolidinone, had ideal properties for use as a linker between drug and NP. To generate the heat necessary for intramolecular cyclization, we have devised a method to covalently load the amino-linkers onto Fe3O4 nanoparticles.

KW - AMF

KW - Controlled release

KW - Intramolecular cyclization

KW - Iron oxide

KW - Nanoparticles

UR - http://www.scopus.com/inward/record.url?scp=84881115172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881115172&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:84881115172

SN - 9781482205862

VL - 3

SP - 251

EP - 254

BT - Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013

T2 - Nanotechnology 2013: Bio Sensors, Instruments, Medical, Environment and Energy - 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013

Y2 - 12 May 2013 through 16 May 2013

ER -

Magnetic field-induced cyclizations of amino-esters and -carbonates bound to iron oxide nanoparticles

Abstract

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Keywords

ASJC Scopus subject areas

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