Magnesium deficiency and blood 2,3-diphosphoglycerate concentrations in sedentary and exercised male osborne-mendel rats

Patricia Lowney, Judith S. Stern, M. Eric Gershwin, Carl L Keen

Research output: Contribution to journalArticle

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Abstract

Magnesium deficiency lowers endurance capacity of untrained rats by an as yet unknown mechanism. We tested the hypothesis that low plasma and blood Mg concentrations would reduce blood 2,3-diphosphoglycerate (2,3-DPG) concentrations, thus diminishing the oxygen delivery system of the Mg-deficient rat. Untrained male Osborne-Mendel rats (95 g) were studied at rest or following exhaustive exercise after three weeks of dietary treatment (400 or 100 μg Mg/g diet; deionized or high Mg water [>85 μg Mg/ml]). Magnesium deficiency resulted in lowered plasma and red blood cell (RBC) Mg concentrations and reduced endurance capacity compared with controls. Magnesium supplementation normalized these parameters. 2,3-DPG was elevated by 10% in rats acutely exercised compared with sedentary rats; however, 2,3-DPG levels were not affected by dietary Mg intake. Acute exercise tended to increase erythrocyte Mg concentrations in control rats and lower erythrocyte Mg levels in deficient rats. In conclusion, the reduced endurance capacity of Mg-deficient rats is not due to impaired 2,3-DPG production.

Original languageEnglish (US)
Pages (from-to)837-841
Number of pages5
JournalMetabolism
Volume39
Issue number8
DOIs
StatePublished - 1990

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Magnesium Deficiency
2,3-Diphosphoglycerate
Erythrocytes
Magnesium
Exercise
Oxygen
Diet
Water

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Magnesium deficiency and blood 2,3-diphosphoglycerate concentrations in sedentary and exercised male osborne-mendel rats. / Lowney, Patricia; Stern, Judith S.; Gershwin, M. Eric; Keen, Carl L.

In: Metabolism, Vol. 39, No. 8, 1990, p. 837-841.

Research output: Contribution to journalArticle

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abstract = "Magnesium deficiency lowers endurance capacity of untrained rats by an as yet unknown mechanism. We tested the hypothesis that low plasma and blood Mg concentrations would reduce blood 2,3-diphosphoglycerate (2,3-DPG) concentrations, thus diminishing the oxygen delivery system of the Mg-deficient rat. Untrained male Osborne-Mendel rats (95 g) were studied at rest or following exhaustive exercise after three weeks of dietary treatment (400 or 100 μg Mg/g diet; deionized or high Mg water [>85 μg Mg/ml]). Magnesium deficiency resulted in lowered plasma and red blood cell (RBC) Mg concentrations and reduced endurance capacity compared with controls. Magnesium supplementation normalized these parameters. 2,3-DPG was elevated by 10{\%} in rats acutely exercised compared with sedentary rats; however, 2,3-DPG levels were not affected by dietary Mg intake. Acute exercise tended to increase erythrocyte Mg concentrations in control rats and lower erythrocyte Mg levels in deficient rats. In conclusion, the reduced endurance capacity of Mg-deficient rats is not due to impaired 2,3-DPG production.",
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N2 - Magnesium deficiency lowers endurance capacity of untrained rats by an as yet unknown mechanism. We tested the hypothesis that low plasma and blood Mg concentrations would reduce blood 2,3-diphosphoglycerate (2,3-DPG) concentrations, thus diminishing the oxygen delivery system of the Mg-deficient rat. Untrained male Osborne-Mendel rats (95 g) were studied at rest or following exhaustive exercise after three weeks of dietary treatment (400 or 100 μg Mg/g diet; deionized or high Mg water [>85 μg Mg/ml]). Magnesium deficiency resulted in lowered plasma and red blood cell (RBC) Mg concentrations and reduced endurance capacity compared with controls. Magnesium supplementation normalized these parameters. 2,3-DPG was elevated by 10% in rats acutely exercised compared with sedentary rats; however, 2,3-DPG levels were not affected by dietary Mg intake. Acute exercise tended to increase erythrocyte Mg concentrations in control rats and lower erythrocyte Mg levels in deficient rats. In conclusion, the reduced endurance capacity of Mg-deficient rats is not due to impaired 2,3-DPG production.

AB - Magnesium deficiency lowers endurance capacity of untrained rats by an as yet unknown mechanism. We tested the hypothesis that low plasma and blood Mg concentrations would reduce blood 2,3-diphosphoglycerate (2,3-DPG) concentrations, thus diminishing the oxygen delivery system of the Mg-deficient rat. Untrained male Osborne-Mendel rats (95 g) were studied at rest or following exhaustive exercise after three weeks of dietary treatment (400 or 100 μg Mg/g diet; deionized or high Mg water [>85 μg Mg/ml]). Magnesium deficiency resulted in lowered plasma and red blood cell (RBC) Mg concentrations and reduced endurance capacity compared with controls. Magnesium supplementation normalized these parameters. 2,3-DPG was elevated by 10% in rats acutely exercised compared with sedentary rats; however, 2,3-DPG levels were not affected by dietary Mg intake. Acute exercise tended to increase erythrocyte Mg concentrations in control rats and lower erythrocyte Mg levels in deficient rats. In conclusion, the reduced endurance capacity of Mg-deficient rats is not due to impaired 2,3-DPG production.

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