Magnamosis III: Delivery of a magnetic compression anastomosis device using minimally invasive endoscopic techniques

Kelly D. Gonzales, Geoffrey Douglas, Kullada O. Pichakron, Dillon A. Kwiat, Salvador Guevara Gallardo, Jose Luis Encinas, Shinjiro Hirose, Michael R. Harrison

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Purpose: Magnamosis creates a secure sutureless anastomosis through magnetic compression. In this study, we further develop and test delivery devices capable of creating a secure duodeno-colonic anastomosis using available minimally invasive endoscopic techniques. Methods: Eight pigs underwent general anesthesia. Colonoscopy was used to deliver 1 magnetic ring to the hepatic flexure. Simultaneously, upper endoscopy delivered the other magnetic ring into the duodenum using a variety of techniques. The 2 magnetic rings were brought into magnetic proximity under laparoscopic guidance. The pigs were recovered and examined daily followed by sacrificing at 1, 2, 4, and 6 weeks. Results: The device designed to deliver and release each magnetic ring evolved from using a guide wire and balloon devices to redesigning the magnetic ring casing with a groove to accommodate an endoscopic snare. Laparoscopic visualization assured safe magnet mating of intestinal segments. The duodeno-colonic anastomoses created with the snare yielded widely patent anastomoses. In vitro testing revealed excellent burst pressure. Histology revealed complete healing as early as 1 week. Conclusion: We redesigned the magnamosis device to facilitate delivery by endoscopic techniques. The snare technique allows endoscopic positioning and controlled release of the magnetic rings for a secure side-to-side duodeno-colonic anastomosis.

Original languageEnglish (US)
Pages (from-to)1291-1295
Number of pages5
JournalJournal of Pediatric Surgery
Volume47
Issue number6
DOIs
StatePublished - Jun 1 2012

Keywords

  • Anastomosis
  • Devices
  • Intestinal surgery
  • Magnamosis
  • Minimally invasive

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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