Abstract
Purpose: Magnamosis creates a secure sutureless anastomosis through magnetic compression. In this study, we further develop and test delivery devices capable of creating a secure duodeno-colonic anastomosis using available minimally invasive endoscopic techniques. Methods: Eight pigs underwent general anesthesia. Colonoscopy was used to deliver 1 magnetic ring to the hepatic flexure. Simultaneously, upper endoscopy delivered the other magnetic ring into the duodenum using a variety of techniques. The 2 magnetic rings were brought into magnetic proximity under laparoscopic guidance. The pigs were recovered and examined daily followed by sacrificing at 1, 2, 4, and 6 weeks. Results: The device designed to deliver and release each magnetic ring evolved from using a guide wire and balloon devices to redesigning the magnetic ring casing with a groove to accommodate an endoscopic snare. Laparoscopic visualization assured safe magnet mating of intestinal segments. The duodeno-colonic anastomoses created with the snare yielded widely patent anastomoses. In vitro testing revealed excellent burst pressure. Histology revealed complete healing as early as 1 week. Conclusion: We redesigned the magnamosis device to facilitate delivery by endoscopic techniques. The snare technique allows endoscopic positioning and controlled release of the magnetic rings for a secure side-to-side duodeno-colonic anastomosis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1291-1295 |
| Number of pages | 5 |
| Journal | Journal of Pediatric Surgery |
| Volume | 47 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2012 |
| Externally published | Yes |
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Keywords
- Anastomosis
- Devices
- Intestinal surgery
- Magnamosis
- Minimally invasive
ASJC Scopus subject areas
- Surgery
- Pediatrics, Perinatology, and Child Health
Cite this
Magnamosis III : Delivery of a magnetic compression anastomosis device using minimally invasive endoscopic techniques. / Gonzales, Kelly D.; Douglas, Geoffrey; Pichakron, Kullada O.; Kwiat, Dillon A.; Guevara, Salvador; Encinas, Jose Luis; Hirose, Shinjiro; Harrison, Michael R.
In: Journal of Pediatric Surgery, Vol. 47, No. 6, 01.06.2012, p. 1291-1295.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Magnamosis III
T2 - Delivery of a magnetic compression anastomosis device using minimally invasive endoscopic techniques
AU - Gonzales, Kelly D.
AU - Douglas, Geoffrey
AU - Pichakron, Kullada O.
AU - Kwiat, Dillon A.
AU - Guevara, Salvador
AU - Encinas, Jose Luis
AU - Hirose, Shinjiro
AU - Harrison, Michael R.
PY - 2012/6/1
Y1 - 2012/6/1
N2 - Purpose: Magnamosis creates a secure sutureless anastomosis through magnetic compression. In this study, we further develop and test delivery devices capable of creating a secure duodeno-colonic anastomosis using available minimally invasive endoscopic techniques. Methods: Eight pigs underwent general anesthesia. Colonoscopy was used to deliver 1 magnetic ring to the hepatic flexure. Simultaneously, upper endoscopy delivered the other magnetic ring into the duodenum using a variety of techniques. The 2 magnetic rings were brought into magnetic proximity under laparoscopic guidance. The pigs were recovered and examined daily followed by sacrificing at 1, 2, 4, and 6 weeks. Results: The device designed to deliver and release each magnetic ring evolved from using a guide wire and balloon devices to redesigning the magnetic ring casing with a groove to accommodate an endoscopic snare. Laparoscopic visualization assured safe magnet mating of intestinal segments. The duodeno-colonic anastomoses created with the snare yielded widely patent anastomoses. In vitro testing revealed excellent burst pressure. Histology revealed complete healing as early as 1 week. Conclusion: We redesigned the magnamosis device to facilitate delivery by endoscopic techniques. The snare technique allows endoscopic positioning and controlled release of the magnetic rings for a secure side-to-side duodeno-colonic anastomosis.
AB - Purpose: Magnamosis creates a secure sutureless anastomosis through magnetic compression. In this study, we further develop and test delivery devices capable of creating a secure duodeno-colonic anastomosis using available minimally invasive endoscopic techniques. Methods: Eight pigs underwent general anesthesia. Colonoscopy was used to deliver 1 magnetic ring to the hepatic flexure. Simultaneously, upper endoscopy delivered the other magnetic ring into the duodenum using a variety of techniques. The 2 magnetic rings were brought into magnetic proximity under laparoscopic guidance. The pigs were recovered and examined daily followed by sacrificing at 1, 2, 4, and 6 weeks. Results: The device designed to deliver and release each magnetic ring evolved from using a guide wire and balloon devices to redesigning the magnetic ring casing with a groove to accommodate an endoscopic snare. Laparoscopic visualization assured safe magnet mating of intestinal segments. The duodeno-colonic anastomoses created with the snare yielded widely patent anastomoses. In vitro testing revealed excellent burst pressure. Histology revealed complete healing as early as 1 week. Conclusion: We redesigned the magnamosis device to facilitate delivery by endoscopic techniques. The snare technique allows endoscopic positioning and controlled release of the magnetic rings for a secure side-to-side duodeno-colonic anastomosis.
KW - Anastomosis
KW - Devices
KW - Intestinal surgery
KW - Magnamosis
KW - Minimally invasive
UR - http://www.scopus.com/inward/record.url?scp=84862490669&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862490669&partnerID=8YFLogxK
U2 - 10.1016/j.jpedsurg.2012.03.042
DO - 10.1016/j.jpedsurg.2012.03.042
M3 - Article
C2 - 22703808
AN - SCOPUS:84862490669
VL - 47
SP - 1291
EP - 1295
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
SN - 0022-3468
IS - 6
ER -