Abstract
Purpose: To describe maculopathy diagnosed with high-resolution Fourier-domain optical coherence tomography among eyes with previously unexplained visual loss. Methods: Nine eyes from six patients with previously unexplained vision loss based on funduscopy, fluorescein angiography, and Stratus optical coherence tomography and 32 eyes from 25 asymptomatic age-matched control subjects were imaged with a Fourierdomain optical coherence tomography instrument with axial resolution of 4 mm to 4.5 mm and transverse resolution of 10 mm to 15 mm. Results: Among eyes with unexplained vision loss, visual acuity ranged from 20/20 to 20/80 and central scotoma was noted in all eyes by microperimetry or Amsler grid. Fourierdomain optical coherence tomography showed abnormality in the foveal photoreceptor (PR) layer in six eyes from four subjects (67%). These abnormalities include focal loss of the PR layer with microcystoid changes in the macula (n = 2), focal discontinuity of the PR layer (n = 3), and focal elevation and blurring of the PR layer associated with a mild epiretinal membrane (n = 1). Among age-matched control eyes, no foveal PR abnormality was seen. Conclusion: Fourier-domain optical coherence tomography detected subtle changes in the foveal PR layer in some eyes with vision loss and central scotoma unexplained with routine clinical diagnostic tests.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 233-239 |
| Number of pages | 7 |
| Journal | Retinal Cases and Brief Reports |
| Volume | 4 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2010 |
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Keywords
- Fourier-domain optical coherence tomography
- High-resolution optical coherence tomography
- Macular microhole
- Maculopathy
- Tamoxifen
- Toxic maculopathy
- Unexplained vision loss
ASJC Scopus subject areas
- Ophthalmology
Cite this
Maculopathy diagnosed with high-resolution Fourier-domain optical coherence tomography in eyes with previously unexplained visual loss. / Park, Susanna Soon Chun; Zawadzki, Robert; Choi, Stacey S.; Werner, John S.
In: Retinal Cases and Brief Reports, Vol. 4, No. 3, 06.2010, p. 233-239.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Maculopathy diagnosed with high-resolution Fourier-domain optical coherence tomography in eyes with previously unexplained visual loss
AU - Park, Susanna Soon Chun
AU - Zawadzki, Robert
AU - Choi, Stacey S.
AU - Werner, John S
PY - 2010/6
Y1 - 2010/6
N2 - Purpose: To describe maculopathy diagnosed with high-resolution Fourier-domain optical coherence tomography among eyes with previously unexplained visual loss. Methods: Nine eyes from six patients with previously unexplained vision loss based on funduscopy, fluorescein angiography, and Stratus optical coherence tomography and 32 eyes from 25 asymptomatic age-matched control subjects were imaged with a Fourierdomain optical coherence tomography instrument with axial resolution of 4 mm to 4.5 mm and transverse resolution of 10 mm to 15 mm. Results: Among eyes with unexplained vision loss, visual acuity ranged from 20/20 to 20/80 and central scotoma was noted in all eyes by microperimetry or Amsler grid. Fourierdomain optical coherence tomography showed abnormality in the foveal photoreceptor (PR) layer in six eyes from four subjects (67%). These abnormalities include focal loss of the PR layer with microcystoid changes in the macula (n = 2), focal discontinuity of the PR layer (n = 3), and focal elevation and blurring of the PR layer associated with a mild epiretinal membrane (n = 1). Among age-matched control eyes, no foveal PR abnormality was seen. Conclusion: Fourier-domain optical coherence tomography detected subtle changes in the foveal PR layer in some eyes with vision loss and central scotoma unexplained with routine clinical diagnostic tests.
AB - Purpose: To describe maculopathy diagnosed with high-resolution Fourier-domain optical coherence tomography among eyes with previously unexplained visual loss. Methods: Nine eyes from six patients with previously unexplained vision loss based on funduscopy, fluorescein angiography, and Stratus optical coherence tomography and 32 eyes from 25 asymptomatic age-matched control subjects were imaged with a Fourierdomain optical coherence tomography instrument with axial resolution of 4 mm to 4.5 mm and transverse resolution of 10 mm to 15 mm. Results: Among eyes with unexplained vision loss, visual acuity ranged from 20/20 to 20/80 and central scotoma was noted in all eyes by microperimetry or Amsler grid. Fourierdomain optical coherence tomography showed abnormality in the foveal photoreceptor (PR) layer in six eyes from four subjects (67%). These abnormalities include focal loss of the PR layer with microcystoid changes in the macula (n = 2), focal discontinuity of the PR layer (n = 3), and focal elevation and blurring of the PR layer associated with a mild epiretinal membrane (n = 1). Among age-matched control eyes, no foveal PR abnormality was seen. Conclusion: Fourier-domain optical coherence tomography detected subtle changes in the foveal PR layer in some eyes with vision loss and central scotoma unexplained with routine clinical diagnostic tests.
KW - Fourier-domain optical coherence tomography
KW - High-resolution optical coherence tomography
KW - Macular microhole
KW - Maculopathy
KW - Tamoxifen
KW - Toxic maculopathy
KW - Unexplained vision loss
UR - http://www.scopus.com/inward/record.url?scp=80052190158&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052190158&partnerID=8YFLogxK
U2 - 10.1097/ICB.0b013e3181ae71ca
DO - 10.1097/ICB.0b013e3181ae71ca
M3 - Article
AN - SCOPUS:80052190158
VL - 4
SP - 233
EP - 239
JO - Retinal Cases and Brief Reports
JF - Retinal Cases and Brief Reports
SN - 1935-1089
IS - 3
ER -