Macrocyclic helix-threading peptides for targeting RNA

Malathy Krishnamurthy; Kristina Simon; Anita M. Orendt; Peter A. Beal

doi:10.1002/anie.200702247

Macrocyclic helix-threading peptides for targeting RNA

Malathy Krishnamurthy, Kristina Simon, Anita M. Orendt, Peter A. Beal

Chemistry

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Hanging on by a thread: RNA-binding macrocyclic helix-threading peptides were synthesized by solid-phase ring-closing metathesis. The cyclic peptide shows improved affinity to a target RNA over its linear precursor. This compound also binds a naturally occurring precursor microRNA target and may be valuable for regulating microRNA function. (Chemical Equation Presented).

Original language	English (US)
Pages (from-to)	7044-7047
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	37
DOIs	https://doi.org/10.1002/anie.200702247
State	Published - 2007

Keywords

microRNA
Peptides
Quinolines
Ring-closing metathesis
RNA recognition

ASJC Scopus subject areas

Chemistry(all)

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10.1002/anie.200702247

Cite this

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title = "Macrocyclic helix-threading peptides for targeting RNA",

abstract = "Hanging on by a thread: RNA-binding macrocyclic helix-threading peptides were synthesized by solid-phase ring-closing metathesis. The cyclic peptide shows improved affinity to a target RNA over its linear precursor. This compound also binds a naturally occurring precursor microRNA target and may be valuable for regulating microRNA function. (Chemical Equation Presented).",

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year = "2007",

doi = "10.1002/anie.200702247",

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T1 - Macrocyclic helix-threading peptides for targeting RNA

AU - Krishnamurthy, Malathy

AU - Simon, Kristina

AU - Orendt, Anita M.

AU - Beal, Peter A.

PY - 2007

Y1 - 2007

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AB - Hanging on by a thread: RNA-binding macrocyclic helix-threading peptides were synthesized by solid-phase ring-closing metathesis. The cyclic peptide shows improved affinity to a target RNA over its linear precursor. This compound also binds a naturally occurring precursor microRNA target and may be valuable for regulating microRNA function. (Chemical Equation Presented).

KW - microRNA

KW - Peptides

KW - Quinolines

KW - Ring-closing metathesis

KW - RNA recognition

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DO - 10.1002/anie.200702247

M3 - Article

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 37

ER -

Macrocyclic helix-threading peptides for targeting RNA

Abstract

Keywords

ASJC Scopus subject areas

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