Macrocyclic helix-threading peptides for targeting RNA

Malathy Krishnamurthy, Kristina Simon, Anita M. Orendt, Peter A. Beal

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Hanging on by a thread: RNA-binding macrocyclic helix-threading peptides were synthesized by solid-phase ring-closing metathesis. The cyclic peptide shows improved affinity to a target RNA over its linear precursor. This compound also binds a naturally occurring precursor microRNA target and may be valuable for regulating microRNA function. (Chemical Equation Presented).

Original languageEnglish (US)
Pages (from-to)7044-7047
Number of pages4
JournalAngewandte Chemie - International Edition
Volume46
Issue number37
DOIs
StatePublished - 2007

Keywords

  • microRNA
  • Peptides
  • Quinolines
  • Ring-closing metathesis
  • RNA recognition

ASJC Scopus subject areas

  • Chemistry(all)

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    Krishnamurthy, M., Simon, K., Orendt, A. M., & Beal, P. A. (2007). Macrocyclic helix-threading peptides for targeting RNA. Angewandte Chemie - International Edition, 46(37), 7044-7047. https://doi.org/10.1002/anie.200702247