Macrocyclic helix-threading peptides for targeting RNA

Malathy Krishnamurthy; Kristina Simon; Anita M. Orendt; Peter A. Beal

doi:10.1002/anie.200702247

Macrocyclic helix-threading peptides for targeting RNA

Malathy Krishnamurthy, Kristina Simon, Anita M. Orendt, Peter A. Beal

Chemistry

Research output: Contribution to journal › Article

55 Scopus citations

Abstract

Hanging on by a thread: RNA-binding macrocyclic helix-threading peptides were synthesized by solid-phase ring-closing metathesis. The cyclic peptide shows improved affinity to a target RNA over its linear precursor. This compound also binds a naturally occurring precursor microRNA target and may be valuable for regulating microRNA function. (Chemical Equation Presented).

Original language	English (US)
Pages (from-to)	7044-7047
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	37
DOIs	https://doi.org/10.1002/anie.200702247
State	Published - 2007

Keywords

microRNA
Peptides
Quinolines
Ring-closing metathesis
RNA recognition

ASJC Scopus subject areas

Chemistry(all)

Access to Document

10.1002/anie.200702247

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Krishnamurthy, M., Simon, K., Orendt, A. M., & Beal, P. A. (2007). Macrocyclic helix-threading peptides for targeting RNA. Angewandte Chemie - International Edition, 46(37), 7044-7047. https://doi.org/10.1002/anie.200702247

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AU - Orendt, Anita M.

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KW - Quinolines

KW - Ring-closing metathesis

KW - RNA recognition

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