Macitentan for the treatment of idiopathic pulmonary fibrosis: The randomised controlled MUSIC trial

Ganesh Raghu; Rachel Million-Rousseau; Adele Morganti; Loïc Perchenet; Juergen Behr; N. Goh; A. Glanville; M. Musk; P. Hopkins; D. C. Lien; C. Chan; J. D. Rolf; P. Wilcox; P. G. Cox; H. Manganas; V. Cottin; D. Valeyre; B. Walleart; S. Andreas; C. Neurohr; A. Guenther; N. Schönfeld; A. Koch; M. Kramer; R. Breuer; I. Ben-Dov; G. Fink; Y. Schwarz; C. Albera; M. Confalonieri; C. Saltini; S. Harari; M. Flezar; M. Greenblatt; G. J. Ras; F. Morell; J. L. Alvarez-Sala; A. Xaubet; A. Sueiro; M. J. Linares; M. Sköld; O. Kayacan; N. Mogulkoc; Andrew Chan; J. Chapman; J. Parambil; N. Ettinger; J. Golden; K. C. Meyer; J. J. Swigris; G. L. Yung; D. Antin-Ozerkis; P. K. Mohabir; L. J. Wesselius; J. De Andrade; F. Cordova; Z. Safdar; M. Wencel

doi:10.1183/09031936.00104612

Macitentan for the treatment of idiopathic pulmonary fibrosis: The randomised controlled MUSIC trial

Ganesh Raghu, Rachel Million-Rousseau, Adele Morganti, Loïc Perchenet, Juergen Behr, N. Goh, A. Glanville, M. Musk, P. Hopkins, D. C. Lien, C. Chan, J. D. Rolf, P. Wilcox, P. G. Cox, H. Manganas, V. Cottin, D. Valeyre, B. Walleart, S. Andreas, C. NeurohrA. Guenther, N. Schönfeld, A. Koch, M. Kramer, R. Breuer, I. Ben-Dov, G. Fink, Y. Schwarz, C. Albera, M. Confalonieri, C. Saltini, S. Harari, M. Flezar, M. Greenblatt, G. J. Ras, F. Morell, J. L. Alvarez-Sala, A. Xaubet, A. Sueiro, M. J. Linares, M. Sköld, O. Kayacan, N. Mogulkoc, Andrew Chan, J. Chapman, J. Parambil, N. Ettinger, J. Golden, K. C. Meyer, J. J. Swigris, G. L. Yung, D. Antin-Ozerkis, P. K. Mohabir, L. J. Wesselius, J. De Andrade, F. Cordova, Z. Safdar, M. Wencel

Pulmonary, Critical Care, and Sleep Medicine

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172 Scopus citations

Abstract

Idiopathic pulmonary fibrosis is a progressive, fatal disease. This prospective, randomised, double-blind, multicentre, parallel-group, placebo-controlled phase II trial (NCT00903331) investigated the efficacy and safety of the endothelin receptor antagonist macitentan in idiopathic pulmonary fibrosis. Eligible subjects were adults with idiopathic pulmonary fibrosis of

Original language	English (US)
Pages (from-to)	1622-1632
Number of pages	11
Journal	European Respiratory Journal
Volume	42
Issue number	6
DOIs	https://doi.org/10.1183/09031936.00104612
State	Published - Dec 1 2013

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1183/09031936.00104612

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Raghu, G., Million-Rousseau, R., Morganti, A., Perchenet, L., Behr, J., Goh, N., Glanville, A., Musk, M., Hopkins, P., Lien, D. C., Chan, C., Rolf, J. D., Wilcox, P., Cox, P. G., Manganas, H., Cottin, V., Valeyre, D., Walleart, B., Andreas, S., ... Wencel, M. (2013). Macitentan for the treatment of idiopathic pulmonary fibrosis: The randomised controlled MUSIC trial. European Respiratory Journal, 42(6), 1622-1632. https://doi.org/10.1183/09031936.00104612

Macitentan for the treatment of idiopathic pulmonary fibrosis : The randomised controlled MUSIC trial. / Raghu, Ganesh; Million-Rousseau, Rachel; Morganti, Adele; Perchenet, Loïc; Behr, Juergen; Goh, N.; Glanville, A.; Musk, M.; Hopkins, P.; Lien, D. C.; Chan, C.; Rolf, J. D.; Wilcox, P.; Cox, P. G.; Manganas, H.; Cottin, V.; Valeyre, D.; Walleart, B.; Andreas, S.; Neurohr, C.; Guenther, A.; Schönfeld, N.; Koch, A.; Kramer, M.; Breuer, R.; Ben-Dov, I.; Fink, G.; Schwarz, Y.; Albera, C.; Confalonieri, M.; Saltini, C.; Harari, S.; Flezar, M.; Greenblatt, M.; Ras, G. J.; Morell, F.; Alvarez-Sala, J. L.; Xaubet, A.; Sueiro, A.; Linares, M. J.; Sköld, M.; Kayacan, O.; Mogulkoc, N.; Chan, Andrew; Chapman, J.; Parambil, J.; Ettinger, N.; Golden, J.; Meyer, K. C.; Swigris, J. J.; Yung, G. L.; Antin-Ozerkis, D.; Mohabir, P. K.; Wesselius, L. J.; De Andrade, J.; Cordova, F.; Safdar, Z.; Wencel, M.

In: European Respiratory Journal, Vol. 42, No. 6, 01.12.2013, p. 1622-1632.

Research output: Contribution to journal › Article › peer-review

Raghu, G, Million-Rousseau, R, Morganti, A, Perchenet, L, Behr, J, Goh, N, Glanville, A, Musk, M, Hopkins, P, Lien, DC, Chan, C, Rolf, JD, Wilcox, P, Cox, PG, Manganas, H, Cottin, V, Valeyre, D, Walleart, B, Andreas, S, Neurohr, C, Guenther, A, Schönfeld, N, Koch, A, Kramer, M, Breuer, R, Ben-Dov, I, Fink, G, Schwarz, Y, Albera, C, Confalonieri, M, Saltini, C, Harari, S, Flezar, M, Greenblatt, M, Ras, GJ, Morell, F, Alvarez-Sala, JL, Xaubet, A, Sueiro, A, Linares, MJ, Sköld, M, Kayacan, O, Mogulkoc, N, Chan, A, Chapman, J, Parambil, J, Ettinger, N, Golden, J, Meyer, KC, Swigris, JJ, Yung, GL, Antin-Ozerkis, D, Mohabir, PK, Wesselius, LJ, De Andrade, J, Cordova, F, Safdar, Z & Wencel, M 2013, 'Macitentan for the treatment of idiopathic pulmonary fibrosis: The randomised controlled MUSIC trial', European Respiratory Journal, vol. 42, no. 6, pp. 1622-1632. https://doi.org/10.1183/09031936.00104612

Raghu, Ganesh ; Million-Rousseau, Rachel ; Morganti, Adele ; Perchenet, Loïc ; Behr, Juergen ; Goh, N. ; Glanville, A. ; Musk, M. ; Hopkins, P. ; Lien, D. C. ; Chan, C. ; Rolf, J. D. ; Wilcox, P. ; Cox, P. G. ; Manganas, H. ; Cottin, V. ; Valeyre, D. ; Walleart, B. ; Andreas, S. ; Neurohr, C. ; Guenther, A. ; Schönfeld, N. ; Koch, A. ; Kramer, M. ; Breuer, R. ; Ben-Dov, I. ; Fink, G. ; Schwarz, Y. ; Albera, C. ; Confalonieri, M. ; Saltini, C. ; Harari, S. ; Flezar, M. ; Greenblatt, M. ; Ras, G. J. ; Morell, F. ; Alvarez-Sala, J. L. ; Xaubet, A. ; Sueiro, A. ; Linares, M. J. ; Sköld, M. ; Kayacan, O. ; Mogulkoc, N. ; Chan, Andrew ; Chapman, J. ; Parambil, J. ; Ettinger, N. ; Golden, J. ; Meyer, K. C. ; Swigris, J. J. ; Yung, G. L. ; Antin-Ozerkis, D. ; Mohabir, P. K. ; Wesselius, L. J. ; De Andrade, J. ; Cordova, F. ; Safdar, Z. ; Wencel, M. / Macitentan for the treatment of idiopathic pulmonary fibrosis : The randomised controlled MUSIC trial. In: European Respiratory Journal. 2013 ; Vol. 42, No. 6. pp. 1622-1632.

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abstract = "Idiopathic pulmonary fibrosis is a progressive, fatal disease. This prospective, randomised, double-blind, multicentre, parallel-group, placebo-controlled phase II trial (NCT00903331) investigated the efficacy and safety of the endothelin receptor antagonist macitentan in idiopathic pulmonary fibrosis. Eligible subjects were adults with idiopathic pulmonary fibrosis of ",

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AU - Million-Rousseau, Rachel

AU - Morganti, Adele

AU - Perchenet, Loïc

AU - Behr, Juergen

AU - Goh, N.

AU - Glanville, A.

AU - Musk, M.

AU - Hopkins, P.

AU - Lien, D. C.

AU - Chan, C.

AU - Rolf, J. D.

AU - Wilcox, P.

AU - Cox, P. G.

AU - Manganas, H.

AU - Cottin, V.

AU - Valeyre, D.

AU - Walleart, B.

AU - Andreas, S.

AU - Neurohr, C.

AU - Guenther, A.

AU - Schönfeld, N.

AU - Koch, A.

AU - Kramer, M.

AU - Breuer, R.

AU - Ben-Dov, I.

AU - Fink, G.

AU - Schwarz, Y.

AU - Albera, C.

AU - Confalonieri, M.

AU - Saltini, C.

AU - Harari, S.

AU - Flezar, M.

AU - Greenblatt, M.

AU - Ras, G. J.

AU - Morell, F.

AU - Alvarez-Sala, J. L.

AU - Xaubet, A.

AU - Sueiro, A.

AU - Linares, M. J.

AU - Sköld, M.

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AU - Mogulkoc, N.

AU - Chan, Andrew

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AU - Ettinger, N.

AU - Golden, J.

AU - Meyer, K. C.

AU - Swigris, J. J.

AU - Yung, G. L.

AU - Antin-Ozerkis, D.

AU - Mohabir, P. K.

AU - Wesselius, L. J.

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Macitentan for the treatment of idiopathic pulmonary fibrosis: The randomised controlled MUSIC trial

Abstract

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