Macaque monkey retrosplenial cortex

II. Cortical afferents

Yasushi Kobayashi, David G Amaral

Research output: Contribution to journalArticle

280 Citations (Scopus)

Abstract

We investigated the cortical afferents of the retrosplenial cortex and the adjacent posterior cingulate cortex (area 23) in the macaque monkey by using the retrograde tracers Fast blue and Diamidino yellow. We quantitatively analyzed the distribution of labeled neurons throughout the cortical mantle. Injections involving the retrosplenial cortex resulted in labeled neurons within the retrosplenial cortex and in areas 23 and 31 (∼78% of the total labeled cells). In the remainder of the cortex, the heaviest projections originated in the hippocampal formation, including the entorhinal cortex, subiculum, presubiculum, and parasubiculum. The parahippocampal and perirhinal cortices also contained many labeled neurons, as did the prefrontal cortex, mainly in areas 46, 9, 10, and 11, and the occipital cortex, mainly area V2. Injections in area 23 also resulted in numerous labeled cells in the posterior cingulate and retrosplenial regions (∼67% of total labeled cells). As in the retrosplenial cortex, injections of area 23 led to many labeled neurons in the frontal cortex, although most of these cells were in areas 9 and 46. Larger numbers of retrogradely labeled cells were also distributed more widely in the posterior parietal cortex, including areas 7a, 7m, LIP, and DP. There were some labeled cells in the parahippocampal cortex. These connections are consistent with the retrosplenial cortex acting as an interface between the working memory functions in the prefrontal areas and the long-term memory encoding in the medial temporal lobe. The posterior cingulate cortex, in contrast, may be more highly associated with visuospatial functions.

Original languageEnglish (US)
Pages (from-to)48-79
Number of pages32
JournalJournal of Comparative Neurology
Volume466
Issue number1
DOIs
StatePublished - Nov 3 2003

Fingerprint

Macaca
Haplorhini
Gyrus Cinguli
Neurons
Injections
Hippocampus
Occipital Lobe
Parahippocampal Gyrus
Entorhinal Cortex
Parietal Lobe
Long-Term Memory
Frontal Lobe
Temporal Lobe
Prefrontal Cortex
Short-Term Memory

Keywords

  • Connections
  • Entorhinal cortex
  • Hippocampal formation
  • Medial temporal lobe
  • Memory
  • Polysensory cortex

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Macaque monkey retrosplenial cortex : II. Cortical afferents. / Kobayashi, Yasushi; Amaral, David G.

In: Journal of Comparative Neurology, Vol. 466, No. 1, 03.11.2003, p. 48-79.

Research output: Contribution to journalArticle

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