M- and L-cones in early infancy: I. VEP responses to receptor-isolating stimuli at 4- and 8-weeks of age

Kenneth Knoblauch, Michelle L. Bieber, John S Werner

Research output: Contribution to journalArticle

20 Scopus citations


A silent-substitution technique combined with measures of the visually-evoked potential (VEP) was used to determine whether M- and L-cones are functional in early infancy. Data were successfully collected from twenty six infants in response to three receptor-isolation conditions (rod, M- and L-cone isolation) and a luminance-modulation condition. The efficacy of the receptor-isolation conditions was first verified by measuring VEP responses from both dichromatic and color-normal adults to each of the receptor-isolation conditions. Both 4- and 8-week-old infants demonstrated VEP responses to the M- and L-cone isolating stimuli, though the amplitude of the the responses at 4-weeks were reduced compared to those at 8-weeks. These data suggest that the functioning of M- and L-cones can be differentiated as early as 4-weeks of age.

Original languageEnglish (US)
Pages (from-to)1753-1764
Number of pages12
JournalVision Research
Issue number12
StatePublished - Jun 1998
Externally publishedYes



  • Infant color vision
  • Silent substitution
  • Visually-evoked potential

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems

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