Métastases to the skull base: Pathophysiology and management

K. A. Jackson, P. J. Donald, J. E. Boqgan, R. Candour-Edwards, W. Meinzek

Research output: Contribution to journalArticle

Abstract

The estimated overall incidence of brain metastasis is in the range of 12 to 35% of all cancer patients. Métastases to the skull base in all likelihood approach these numbers. Neurosurgical data over the past 10 years demonstrates that resection of a single metastasis not only can improve a patient's neurologic condition but can also increase the rates of local control and survival. Owing to advanced surgical approaches to the basicranium and microsurgical technique, lesions previously considered unresectable can now be removed. Skull base metastasis can spread by tumor emboli through both arterial and venous systems. A detailed anatomical review is presented. Direct extension and perineural spread are discussed. A syndrome classification system is presented based on the location of the metastasis. Signs, symptoms and diagnostic evaluations are discussed. Case presentations along with pathologic and radiologie studies are shown. Resection of skull base metastasis may improve survival and reduce neurologic symptoms in selected patients.

Original languageEnglish (US)
Pages (from-to)27
Number of pages1
JournalSkull Base Surgery
Volume7
Issue numberSUPPL. 1
StatePublished - 1997

Fingerprint

Skull Base
Neoplasm Metastasis
Symptom Assessment
Survival
Neurologic Manifestations
Embolism
Nervous System
Signs and Symptoms
Neoplasms
Incidence
Brain

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Jackson, K. A., Donald, P. J., Boqgan, J. E., Candour-Edwards, R., & Meinzek, W. (1997). Métastases to the skull base: Pathophysiology and management. Skull Base Surgery, 7(SUPPL. 1), 27.

Métastases to the skull base : Pathophysiology and management. / Jackson, K. A.; Donald, P. J.; Boqgan, J. E.; Candour-Edwards, R.; Meinzek, W.

In: Skull Base Surgery, Vol. 7, No. SUPPL. 1, 1997, p. 27.

Research output: Contribution to journalArticle

Jackson, KA, Donald, PJ, Boqgan, JE, Candour-Edwards, R & Meinzek, W 1997, 'Métastases to the skull base: Pathophysiology and management', Skull Base Surgery, vol. 7, no. SUPPL. 1, pp. 27.
Jackson KA, Donald PJ, Boqgan JE, Candour-Edwards R, Meinzek W. Métastases to the skull base: Pathophysiology and management. Skull Base Surgery. 1997;7(SUPPL. 1):27.
Jackson, K. A. ; Donald, P. J. ; Boqgan, J. E. ; Candour-Edwards, R. ; Meinzek, W. / Métastases to the skull base : Pathophysiology and management. In: Skull Base Surgery. 1997 ; Vol. 7, No. SUPPL. 1. pp. 27.
@article{cdc1f78981334bc98d5b6b4484dc589d,
title = "M{\'e}tastases to the skull base: Pathophysiology and management",
abstract = "The estimated overall incidence of brain metastasis is in the range of 12 to 35{\%} of all cancer patients. M{\'e}tastases to the skull base in all likelihood approach these numbers. Neurosurgical data over the past 10 years demonstrates that resection of a single metastasis not only can improve a patient's neurologic condition but can also increase the rates of local control and survival. Owing to advanced surgical approaches to the basicranium and microsurgical technique, lesions previously considered unresectable can now be removed. Skull base metastasis can spread by tumor emboli through both arterial and venous systems. A detailed anatomical review is presented. Direct extension and perineural spread are discussed. A syndrome classification system is presented based on the location of the metastasis. Signs, symptoms and diagnostic evaluations are discussed. Case presentations along with pathologic and radiologie studies are shown. Resection of skull base metastasis may improve survival and reduce neurologic symptoms in selected patients.",
author = "Jackson, {K. A.} and Donald, {P. J.} and Boqgan, {J. E.} and R. Candour-Edwards and W. Meinzek",
year = "1997",
language = "English (US)",
volume = "7",
pages = "27",
journal = "Journal of Neurological Surgery, Part B: Skull Base",
issn = "2193-6331",
publisher = "Thieme Medical Publishers",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Métastases to the skull base

T2 - Pathophysiology and management

AU - Jackson, K. A.

AU - Donald, P. J.

AU - Boqgan, J. E.

AU - Candour-Edwards, R.

AU - Meinzek, W.

PY - 1997

Y1 - 1997

N2 - The estimated overall incidence of brain metastasis is in the range of 12 to 35% of all cancer patients. Métastases to the skull base in all likelihood approach these numbers. Neurosurgical data over the past 10 years demonstrates that resection of a single metastasis not only can improve a patient's neurologic condition but can also increase the rates of local control and survival. Owing to advanced surgical approaches to the basicranium and microsurgical technique, lesions previously considered unresectable can now be removed. Skull base metastasis can spread by tumor emboli through both arterial and venous systems. A detailed anatomical review is presented. Direct extension and perineural spread are discussed. A syndrome classification system is presented based on the location of the metastasis. Signs, symptoms and diagnostic evaluations are discussed. Case presentations along with pathologic and radiologie studies are shown. Resection of skull base metastasis may improve survival and reduce neurologic symptoms in selected patients.

AB - The estimated overall incidence of brain metastasis is in the range of 12 to 35% of all cancer patients. Métastases to the skull base in all likelihood approach these numbers. Neurosurgical data over the past 10 years demonstrates that resection of a single metastasis not only can improve a patient's neurologic condition but can also increase the rates of local control and survival. Owing to advanced surgical approaches to the basicranium and microsurgical technique, lesions previously considered unresectable can now be removed. Skull base metastasis can spread by tumor emboli through both arterial and venous systems. A detailed anatomical review is presented. Direct extension and perineural spread are discussed. A syndrome classification system is presented based on the location of the metastasis. Signs, symptoms and diagnostic evaluations are discussed. Case presentations along with pathologic and radiologie studies are shown. Resection of skull base metastasis may improve survival and reduce neurologic symptoms in selected patients.

UR - http://www.scopus.com/inward/record.url?scp=33747808911&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747808911&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:33747808911

VL - 7

SP - 27

JO - Journal of Neurological Surgery, Part B: Skull Base

JF - Journal of Neurological Surgery, Part B: Skull Base

SN - 2193-6331

IS - SUPPL. 1

ER -