Métastases to the skull base: Pathophysiology and management

K. A. Jackson, P. J. Donald, J. E. Boqgan, R. Candour-Edwards, W. Meinzek

Research output: Contribution to journalArticlepeer-review


The estimated overall incidence of brain metastasis is in the range of 12 to 35% of all cancer patients. Métastases to the skull base in all likelihood approach these numbers. Neurosurgical data over the past 10 years demonstrates that resection of a single metastasis not only can improve a patient's neurologic condition but can also increase the rates of local control and survival. Owing to advanced surgical approaches to the basicranium and microsurgical technique, lesions previously considered unresectable can now be removed. Skull base metastasis can spread by tumor emboli through both arterial and venous systems. A detailed anatomical review is presented. Direct extension and perineural spread are discussed. A syndrome classification system is presented based on the location of the metastasis. Signs, symptoms and diagnostic evaluations are discussed. Case presentations along with pathologic and radiologie studies are shown. Resection of skull base metastasis may improve survival and reduce neurologic symptoms in selected patients.

Original languageEnglish (US)
Pages (from-to)27
Number of pages1
JournalSkull Base Surgery
Issue numberSUPPL. 1
StatePublished - 1997

ASJC Scopus subject areas

  • Clinical Neurology


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