Lymphosarcoma with leukemia in a horse.

B. R. Madewell, Gary Carlson, Nigel J Maclachlan, B. F. Feldman

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


A 17-year-old Arabian gelding was presented because of CNS depression and weight loss. Physical examination revealed generalized lymphadenopathy, pitting edema, and ascites. The diagnosis of lymphosarcoma with leukemic manifestations was based on cytologic and histopathologic examination of lymph node biopsy samples and a peripheral leukocyte count of 98,300/microliters, 94% of which were mature lymphocytes. These circulating lymphocytes lacked B-lymphocyte markers and did not respond to mitogenic stimulation, indicating functional incompetence. Though ultrastructural findings were equivocal, most morphologic changes indicated these cells were of T-lymphocyte lineage. Virus particles were not observed during transmission electron microscopy of these lymphocytes.

Original languageEnglish (US)
Pages (from-to)807-812
Number of pages6
JournalAmerican Journal of Veterinary Research
Issue number5
StatePublished - May 1982
Externally publishedYes

ASJC Scopus subject areas

  • veterinary(all)


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